Simple Discharge Subtypes Predict 3‑Month Mortality and 1‑Year Disability After Sepsis: Validation in the CLOVERS Cohort

Highlight

– A simple algorithm using Charlson Comorbidity Index, hospital length of stay, and discharge destination can assign sepsis survivors into five distinct subtypes at discharge.
– In 1,368 survivors from the CLOVERS trial, subtype assignment strongly discriminated 3‑month mortality (overall 13.1%; subtype range 5.1%–45.5%) with age‑adjusted odds ratios >9 for two high‑risk subtypes versus the low‑risk group.
– Subtypes were also associated with 6‑ and 12‑month health‑related quality of life (EQ‑5D‑5L) and limitations in activities of daily living (ADLs), but not with readmission.
– Readily available discharge data could be used to prioritize survivors for intensified follow‑up, rehabilitation, and advance care planning.

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