Revealing Brain Connectivity Disruptions to Predict Long-Term Seizure Recurrence After Temporal Lobe Epilepsy Surgery

Highlight

• Long-term seizure recurrence after temporal lobe epilepsy surgery is linked to disruption in brain network hubs, notably the hippocampi and dorsal attention network.
• Combining structural and functional MRI-derived connectomes enhances the accuracy of predicting seizure recurrence over clinical variables alone.
• Machine learning models using normative hub disruption metrics demonstrate high specificity and have potential for clinical risk stratification post-surgery.
• Identified biomarkers indicate seizure recurrence drivers may extend beyond resected temporal regions, suggesting broader network involvement.

Study Background