Retatrutide in Type 2 Diabetes and MASLD: Integrative Evidence on Body Composition and Liver Fat Reduction
Highlights
- Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, induces superior reductions in total body fat and liver fat compared with placebo and active controls in type 2 diabetes and metabolic-associated steatotic liver disease (MASLD).
- Lean mass loss is proportionate to weight loss, aligning with other anti-obesity therapies, alleviating concerns regarding excessive lean mass reduction.
- Retatrutide demonstrates robust improvements in metabolic parameters, including insulin sensitivity and lipid metabolism, with an acceptable safety profile.
Clinical Background and Disease Burden
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.