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Rapid-Acting Neuroplastogen TSND-201 Shows Significant Efficacy in PTSD: Results from the Phase 2 IMPACT-1 Trial

MedXY Editorial Team•Feb 20, 2026•news
PsychopharmacologyPTSD

Highlights

TSND-201 (methylone) demonstrated a statistically significant reduction in CAPS-5 total severity scores compared to placebo at day 64 (p = .01).

Significant improvements were observed across secondary endpoints, including the PTSD Checklist for DSM-5 (PCL-5), Sheehan Disability Scale (SDS), and Montgomery-Åsberg Depression Rating Scale (MADRS).

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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