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This review synthesizes evidence from a pivotal randomized clinical trial and complementary literature on psychotherapeutic interventions addressing the psychological impact of killing in war, emphasizing improvements in PTSD, moral injury,
The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.
Qualitative interviews show family PTSD after ICU care is shaped by cumulative stressors across the illness trajectory, highlighting the need for continuous, family-centered communication and support.
A Bayesian adaptive randomized clinical trial reveals that a digital imagery-competing task intervention (ICTI) significantly reduces the frequency of intrusive memories and PTSD symptoms among healthcare workers exposed to pandemic-related
A Phase 2 randomized clinical trial demonstrates that TSND-201, a novel neuroplastogen, significantly reduces PTSD symptoms and functional disability without intensive psychotherapy, offering a potentially rapid and durable treatment option
A large-scale longitudinal study reveals that children whose parents suffer firearm injuries face a significant increase in psychiatric diagnoses, particularly trauma-related disorders. These findings highlight the profound secondary psycho
A comprehensive meta-analysis of over 22 million individuals identifies mental disorders, particularly PTSD and sleep disturbances, as major independent risk factors for acute coronary syndrome, urging a paradigm shift toward integrated car
A large-scale cohort study demonstrates that while hormonal contraceptives are generally associated with lower cardiovascular risk in women, this protective effect is lost in those with PTSD, highlighting a critical intersection between psy
The CLARO randomized clinical trial investigated whether a collaborative care model could improve outcomes for patients with opioid use disorder and co-occurring depression or PTSD. The study found no statistically significant advantages ov
This multicenter longitudinal study reveals that delusional memories, rather than simple amnesia, are the primary predictors of persistent PTSD symptoms following critical illness, highlighting the critical roles of delirium and sedation in
A living systematic review of 30 RCTs (n=1,480) finds moderate-to-large symptom reductions for MDMA in PTSD and serotonergic psychedelics in major depression and anxiety, but high risk of bias and low certainty overall; pragmatic, longer, a
A pragmatic trial comparing SSRIs and written exposure therapy in primary care PTSD treatment found similar effectiveness initially; switching to SNRI was superior to WET augmentation for SSRI nonresponders.
A systematic synthesis of clinical practice guideline recommendations for preventing and managing mental disorders after traumatic injury, with prioritized, implementable actions for acute and early recovery care.
