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– Six plasma proteins were identified as significantly associated with progression from impaired fasting glucose (IFG) to diabetes within 3 years.
– Key proteins included adiponectin and receptor-type tyrosine-protein phosphatase S, implicating altered carbohydrate metabolism and glycolysis pathways.
– Incorporation of these protein markers improved diabetes risk prediction models beyond traditional clinical and demographic factors.
– Two proteins were externally validated in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort, enhancing generalizability.
