Expanding the Proteomic Landscape of Venous Thromboembolism: Novel Biomarkers and Causal Insights from Large-Scale Cohort Meta-Analyses

Highlights

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• Identification of 23 plasma proteins significantly associated with incident venous thromboembolism (VTE) risk, 15 of which are novel to VTE pathophysiology.

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• Utilization of high-throughput aptamer-based (SomaScan) and antibody-based (Olink) platforms across five major longitudinal cohorts (ARIC, CHS, MESA, HUNT, and UK Biobank).

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• Mendelian Randomization (MR) analyses provided evidence for potential causal roles of TIMD4, TIMP4, and CST3 in VTE development.

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• Identified markers shift the focus from traditional coagulation factors toward extracellular matrix regulation, immune-vascular interactions, and vascular senescence.

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