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Personalized Low-Dose Aspirin Use for Cancer Prevention in Older Adults

MedXY Editorial Team•Sep 25, 2025•Clinical Updates
cancer preventionClonal hematopoiesisolder adults

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This secondary analysis of the ASPREE randomized clinical trial identifies heterogeneous effects of low-dose aspirin (LDA) for cancer prevention among older adults. It pinpoints clonal hematopoiesis of indeterminate potential (CHIP) as the strongest individual predictor of aspirin benefit. Personalized treatment prediction models enabled improved 5-year absolute cancer risk reduction versus a universal aspirin approach.

Study Background and Disease Burden

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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Designing Cardiovascular Outcomes Trials in Clonal Hematopoiesis: A Precision Medicine Imperative
Clonal hematopoiesis of indeterminate potential (CHIP) poses a novel cardiovascular risk. This article explores challenges and strategies for designing cardiovascular outcomes trials tailored to CHIP’s genetic heterogeneity and clinical com
Sep 15, 2026
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