PCOS as a Biological Model for Reproductive Longevity: Enhanced Ovarian Reserve and ART Success in Aging Asian Women

MedXY Editorial Team•Dec 25, 2025•Diabetes & Endocrinology

Asian women with Polycystic Ovary Syndrome (PCOS) demonstrate a significantly slower age-related decline in Anti-Müllerian Hormone (AMH) levels compared to normo-ovulatory peers.
In women aged 36 and older, those with PCOS maintained AMH levels more than double those of the control group (44.4 vs 19.3 pmol/l).
Cumulative pregnancy rates (CPR) following Assisted Reproductive Technology (ART) remained stable at approximately 56% for PCOS patients across age groups, whereas normo-ovulatory women saw a sharp decline to 28.6% after age 36.
PCOS may represent a unique human model for studying the mechanisms of reproductive longevity and delayed ovarian senescence.

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Asian women with Polycystic Ovary Syndrome (PCOS) demonstrate a significantly slower age-related decline in Anti-Müllerian Hormone (AMH) levels compared to normo-ovulatory peers.
In women aged 36 and older, those with PCOS maintained AMH levels more than double those of the control group (44.4 vs 19.3 pmol/l).
Cumulative pregnancy rates (CPR) following Assisted Reproductive Technology (ART) remained stable at approximately 56% for PCOS patients across age groups, whereas normo-ovulatory women saw a sharp decline to 28.6% after age 36.
PCOS may represent a unique human model for studying the mechanisms of reproductive longevity and delayed ovarian senescence.