Late-Onset Leber Hereditary Optic Neuropathy: Environmental Triggers, Genetic Factors, and Visual Recovery Insights from a Large Italian Cohort
Highlight
– Late-onset LHON differs from classical LHON with a lower male predominance and significant environmental and hormonal influences.
– High-dose idebenone (≥900 mg/day) is associated with improved visual recovery, particularly in patients harboring J or T mitochondrial haplogroups.
– Smoking and postmenopausal status are prevalent among late-onset LHON patients, suggesting these as potential disease conversion triggers.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.