Incidence, Outcomes, and Risk Factors for Mortality in Patients With Sepsis in South Korea: Insights From a Nationwide Cohort Study and Related Evidence

MedXY Editorial Team•Aug 17, 2026•Clinical Updates

Nationwide data reveal a significant increase in sepsis incidence in South Korea from 2011 to 2022, with crude incidence rate rising from 141.8 to 337.3 per 100,000 person-years.
In-hospital mortality rates declined substantially over the same period, decreasing from 27.0% to 17.0%, despite an absolute increase in total deaths due to rising case volume.
Older age, male sex, higher comorbidity burden, and greater disease severity are consistent independent risk factors for mortality; socioeconomic disparities persist, with higher mortality among medical aid beneficiaries and rural residents.
Complementary studies highlight the impact of sepsis on long-term outcomes, importance of early antibiotic administration, and burden of resistant infections, informing comprehensive management strategies.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Nationwide data reveal a significant increase in sepsis incidence in South Korea from 2011 to 2022, with crude incidence rate rising from 141.8 to 337.3 per 100,000 person-years.
In-hospital mortality rates declined substantially over the same period, decreasing from 27.0% to 17.0%, despite an absolute increase in total deaths due to rising case volume.
Older age, male sex, higher comorbidity burden, and greater disease severity are consistent independent risk factors for mortality; socioeconomic disparities persist, with higher mortality among medical aid beneficiaries and rural residents.
Complementary studies highlight the impact of sepsis on long-term outcomes, importance of early antibiotic administration, and burden of resistant infections, informing comprehensive management strategies.