Highlight
– Immediate complete revascularisation during index STEMI admission was not proven non-inferior to staged revascularisation.
– At 1 year, primary composite outcomes (death, non-fatal MI, unplanned revascularisation) were similar but numerically higher in immediate group.
– Safety profiles, including stroke, bleeding, and contrast-induced nephropathy, were comparable, but cardiogenic shock was more frequent with immediate revascularisation.
– Results may influence guideline recommendations on timing of non-culprit lesion PCI in STEMI with multivessel disease.
