Imaging-Detected Extranodal Extension as a Predictor of Distant Recurrence in HPV-Positive Oropharyngeal Cancer
Highlight
– Imaging-detected extranodal extension (iENE) identifies HPV-positive oropharyngeal cancer patients at increased risk of distant recurrence.
– Grade 3 iENE significantly correlates with worse progression-free survival and higher rates of distant metastasis.
– Incorporation of iENE status into staging systems could improve prognostic accuracy and guide personalized treatment.
– Locoregional control remains comparable regardless of iENE presence, emphasizing distant metastasis as the key adverse outcome.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.