Management of Graves’ Disease During Pregnancy: Clinical Insights from the Danish PRETHYR Multicenter Study

Highlights

• The Danish PRETHYR multicenter study provides the first comprehensive report on clinical management patterns for hyperthyroidism in pregnant women in Denmark.
• Approximately 58.8% of women with known preconception thyroid disease required antithyroid drug (ATD) therapy during pregnancy.
• A significant proportion of patients (59.1%) were switched from methimazole (MMI) to propylthiouracil (PTU) prior to conception to minimize teratogenic risks.
• Higher pre-conception TRAb and lower TSH levels were identified as primary clinical indicators for the continuation or initiation of ATD therapy during the first trimester.

Background: The Challenge of Gestational Hyperthyroidism