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Hospitalization Burden and Outcomes in Congenital Adrenal Hyperplasia Across the Lifespan: Insights from a Swiss Population-Based Cohort Study
Diabetes & Endocrinologyendocrinologyepidemiology

Hospitalization Burden and Outcomes in Congenital Adrenal Hyperplasia Across the Lifespan: Insights from a Swiss Population-Based Cohort Study

By MedXY|Sep 12, 2026

This study reveals that individuals with Congenital Adrenal Hyperplasia (CAH) experience early, frequent, and complex hospitalizations with higher risk of severe outcomes, especially in infancy, compared to non-CAH patients, emphasizing the

Steroids, Stress, and Body Mass Index Interact to Accelerate Female Pubertal Development
Diabetes & EndocrinologyBMI
© 2026 MedXY
Contact usAbout usPrivacy PolicyMedXY story
endocrinology

Steroids, Stress, and Body Mass Index Interact to Accelerate Female Pubertal Development

By MedXY|Aug 19, 2026

Elevated glucocorticoids, androgens, and progesterone metabolites, combined with high BMI and stress, accelerate the onset of puberty in girls, particularly breast development (thelarche).

Phase 2 Study of XP-8121: Once-Weekly Subcutaneous Levothyroxine for Adult Hypothyroidism
Diabetes & EndocrinologyendocrinologyHypothyroidism

Phase 2 Study of XP-8121: Once-Weekly Subcutaneous Levothyroxine for Adult Hypothyroidism

By MedXY|Jun 5, 2026

A Phase 2 trial found that once-weekly subcutaneous levothyroxine (XP-8121) was generally well tolerated and suggested a dose conversion of about four times the daily oral dose for adults with hypothyroidism.

Children Born SGA Receiving Growth Hormone Have Similarly Impaired Glucose-Insulin Metabolism as Children With Obesity
Diabetes & Endocrinologyendocrinologygrowth hormone therapy

Children Born SGA Receiving Growth Hormone Have Similarly Impaired Glucose-Insulin Metabolism as Children With Obesity

By MedXY|May 19, 2026

Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.

Hormones and Aging, Not Just Diet: Unmasking the Sex-Specific Drivers of Plasma Ketone Levels
Diabetes & EndocrinologyendocrinologyKetone Bodies

Hormones and Aging, Not Just Diet: Unmasking the Sex-Specific Drivers of Plasma Ketone Levels

By MedXY|Mar 22, 2026

A large-scale analysis of the PREVEND cohort reveals that fasting β-hydroxybutyrate levels are primarily driven by sex-specific factors: oral contraceptives and menopause in women, and aging in men, challenging the dietary-centric view of k

Impact of Polygenic Risk Scores on the Clinical Presentation and Glycaemic Variability of GCK-MODY
Diabetes & EndocrinologyendocrinologyGCK-MODY

Impact of Polygenic Risk Scores on the Clinical Presentation and Glycaemic Variability of GCK-MODY

By MedXY|Mar 20, 2026

This article explores how polygenic background modifies GCK-MODY clinical phenotypes, influencing HbA1c levels and diagnostic thresholds. Findings highlight the distinct polygenic patterns in GCK-MODY compared to HNF1A-MODY, emphasizing the

Metformin-Induced Blunting of Exercise-Mediated Vascular Improvements in Adults with Metabolic Risk
Cardiologyendocrinologymetabolic syndrome

Metformin-Induced Blunting of Exercise-Mediated Vascular Improvements in Adults with Metabolic Risk

By MedXY|Mar 20, 2026

This report examines how metformin may interfere with exercise-induced improvements in vascular insulin sensitivity and aerobic fitness in adults at risk for metabolic syndrome.

Breaking the Fasting Mandate: Is It Time to Re-evaluate Levothyroxine Administration?
Diabetes & EndocrinologyendocrinologyHypothyroidism

Breaking the Fasting Mandate: Is It Time to Re-evaluate Levothyroxine Administration?

By MedXY|Mar 17, 2026

A randomized clinical trial demonstrates that a 15% dose increase allows levothyroxine to be taken with breakfast without compromising TSH stability, significantly improving patient preference and well-being.

Beyond Thyroglobulin: Uncovering the Alternative Path for Thyroid Hormone Synthesis
Diabetes & EndocrinologyendocrinologyThyroglobulin

Beyond Thyroglobulin: Uncovering the Alternative Path for Thyroid Hormone Synthesis

By MedXY|Mar 10, 2026

This study explores how the body synthesizes thyroid hormones without thyroglobulin, the primary precursor protein. Research using Tg-KO mice reveals an inefficient but life-sustaining mechanism involving goiter growth and the iodination of

Management of Graves’ Disease During Pregnancy: Clinical Insights from the Danish PRETHYR Multicenter Study
Clinical UpdatesendocrinologyGraves' Disease

Management of Graves’ Disease During Pregnancy: Clinical Insights from the Danish PRETHYR Multicenter Study

By MedXY|Mar 9, 2026

This clinical review synthesizes findings from the PRETHYR study on antithyroid drug use in pregnant women, highlighting treatment transitions, biochemical predictors, and the impact of specialist-led management in Denmark.

Beyond Mandatory Resection: Active Surveillance Proves Safe for RAS-Positive Thyroid Nodules
Diabetes & Endocrinologyactive surveillanceendocrinology

Beyond Mandatory Resection: Active Surveillance Proves Safe for RAS-Positive Thyroid Nodules

By MedXY|Mar 6, 2026

A new study suggests that isolated RAS mutations in Bethesda III and IV thyroid nodules do not always require surgery. With a 34% malignancy rate and low growth incidence, active surveillance emerges as a viable, safe alternative for approp

Oxygen-Guided Success: A New Frontier in Adrenal Venous Sampling for Primary Aldosteronism
Diabetes & EndocrinologyAdrenal Venous Samplingendocrinology

Oxygen-Guided Success: A New Frontier in Adrenal Venous Sampling for Primary Aldosteronism

By MedXY|Mar 6, 2026

Researchers have discovered that measuring oxygen partial pressure (pO2) can significantly improve the accuracy and speed of Adrenal Venous Sampling, providing a cost-effective tool for diagnosing Primary Aldosteronism.

PTH-Guided Selective Calcium Supplementation After Total Thyroidectomy: Is Routine Prophylaxis Still Necessary?
General SurgeryendocrinologyHypocalcemia

PTH-Guided Selective Calcium Supplementation After Total Thyroidectomy: Is Routine Prophylaxis Still Necessary?

By MedXY|Feb 19, 2026

A multicenter randomized clinical trial demonstrates that selective calcium supplementation based on early postoperative PTH levels is as effective as routine prophylaxis in preventing hypocalcemia after total thyroidectomy, offering a stra

Managing Obesity as a Chronic Disease: The 2026 WHO Guidelines on GLP-1 Therapies
Diabetes & EndocrinologyendocrinologyGLP-1

Managing Obesity as a Chronic Disease: The 2026 WHO Guidelines on GLP-1 Therapies

By MedXY|Feb 5, 2026

The World Health Organization (WHO) has released its landmark 2026 guidelines on GLP-1 therapies for obesity, reclassifying the condition as a chronic, relapsing disease requiring long-term pharmacological and behavioral management while em

Selenium Supplementation Fails to Improve Remission or Quality of Life in Graves’ Hyperthyroidism: Findings from the GRASS RCT
Diabetes & Endocrinologyclinical trialendocrinology

Selenium Supplementation Fails to Improve Remission or Quality of Life in Graves’ Hyperthyroidism: Findings from the GRASS RCT

By MedXY|Jan 1, 2026

The GRASS trial, a double-blind multi-centre RCT, found that adding 200 µg of selenium daily to standard antithyroid drug therapy does not increase remission rates or improve quality of life in patients with newly diagnosed Graves’ hy

How Birth Control Pills and Smoking Reshape Steroid Hormones
Diabetes & Endocrinologyendocrinologyoral contraceptives

How Birth Control Pills and Smoking Reshape Steroid Hormones

By MedXY|Oct 2, 2025

A large study shows oral contraceptives and smoking substantially alter steroid hormone profiles in healthy adults, with implications for disease risk, diagnostics, and treatment decisions.

30 Practical Tips for Effective and Healthy Weight Loss
Family Medicine & Nutritionendocrinologyexercise tips

30 Practical Tips for Effective and Healthy Weight Loss

By MedXY|Oct 1, 2025

Discover 30 scientifically backed tips from an endocrinologist to help you lose weight healthily and sustainably through diet, exercise, and lifestyle changes.

Top U.S. Hospitals for Diabetes and Endocrinology: Interpreting the 2025–2026 U.S. News Rankings
Diabetes & Endocrinologydiabetesendocrinology

Top U.S. Hospitals for Diabetes and Endocrinology: Interpreting the 2025–2026 U.S. News Rankings

By MedXY|Sep 30, 2025

A critical analysis of the 2025–2026 U.S. News rankings for diabetes and endocrinology care, examining methodology, clinical impact, and implications for patient care and referral.

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