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This study reveals that individuals with Congenital Adrenal Hyperplasia (CAH) experience early, frequent, and complex hospitalizations with higher risk of severe outcomes, especially in infancy, compared to non-CAH patients, emphasizing the
Elevated glucocorticoids, androgens, and progesterone metabolites, combined with high BMI and stress, accelerate the onset of puberty in girls, particularly breast development (thelarche).
A Phase 2 trial found that once-weekly subcutaneous levothyroxine (XP-8121) was generally well tolerated and suggested a dose conversion of about four times the daily oral dose for adults with hypothyroidism.
Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.
A large-scale analysis of the PREVEND cohort reveals that fasting β-hydroxybutyrate levels are primarily driven by sex-specific factors: oral contraceptives and menopause in women, and aging in men, challenging the dietary-centric view of k
This article explores how polygenic background modifies GCK-MODY clinical phenotypes, influencing HbA1c levels and diagnostic thresholds. Findings highlight the distinct polygenic patterns in GCK-MODY compared to HNF1A-MODY, emphasizing the
This report examines how metformin may interfere with exercise-induced improvements in vascular insulin sensitivity and aerobic fitness in adults at risk for metabolic syndrome.
A randomized clinical trial demonstrates that a 15% dose increase allows levothyroxine to be taken with breakfast without compromising TSH stability, significantly improving patient preference and well-being.
This study explores how the body synthesizes thyroid hormones without thyroglobulin, the primary precursor protein. Research using Tg-KO mice reveals an inefficient but life-sustaining mechanism involving goiter growth and the iodination of
This clinical review synthesizes findings from the PRETHYR study on antithyroid drug use in pregnant women, highlighting treatment transitions, biochemical predictors, and the impact of specialist-led management in Denmark.
A new study suggests that isolated RAS mutations in Bethesda III and IV thyroid nodules do not always require surgery. With a 34% malignancy rate and low growth incidence, active surveillance emerges as a viable, safe alternative for approp
Researchers have discovered that measuring oxygen partial pressure (pO2) can significantly improve the accuracy and speed of Adrenal Venous Sampling, providing a cost-effective tool for diagnosing Primary Aldosteronism.
A multicenter randomized clinical trial demonstrates that selective calcium supplementation based on early postoperative PTH levels is as effective as routine prophylaxis in preventing hypocalcemia after total thyroidectomy, offering a stra
The World Health Organization (WHO) has released its landmark 2026 guidelines on GLP-1 therapies for obesity, reclassifying the condition as a chronic, relapsing disease requiring long-term pharmacological and behavioral management while em
The GRASS trial, a double-blind multi-centre RCT, found that adding 200 µg of selenium daily to standard antithyroid drug therapy does not increase remission rates or improve quality of life in patients with newly diagnosed Graves’ hy
A large study shows oral contraceptives and smoking substantially alter steroid hormone profiles in healthy adults, with implications for disease risk, diagnostics, and treatment decisions.
Discover 30 scientifically backed tips from an endocrinologist to help you lose weight healthily and sustainably through diet, exercise, and lifestyle changes.
A critical analysis of the 2025–2026 U.S. News rankings for diabetes and endocrinology care, examining methodology, clinical impact, and implications for patient care and referral.
