FFR-Guided Complete Revascularization Enhances Outcomes in NSTEMI with Multivessel Disease: Insights from the SLIM Trial

Highlight

• FFR-guided complete revascularization significantly reduces the composite risk of death, nonfatal myocardial infarction, repeat revascularizations, and stroke compared to culprit-only PCI in NSTEMI patients with multivessel disease.
• The benefit is largely driven by a notable reduction in repeat revascularization procedures over 1 year.
• Complete revascularization was safely performed during the index procedure without increase in major adverse events despite longer procedure time and higher contrast use.
• These findings support FFR-guided complete revascularization as a strategic standard in managing NSTEMI with multivessel coronary artery disease.

Introduction