Highlight
– Extended exposure to sugar rationing in the first 1000 days after conception associates with a 20-30% reduction in multiple cardiovascular outcomes in adulthood.
– The study leverages a natural experiment using UK birth cohorts around the 1953 end of sugar rationing.
– Diabetes and hypertension partly mediate the cardiovascular risk reduction linked to early sugar restriction.
– Cardiac magnetic resonance imaging reveals modest improvements in left ventricular stroke volume and ejection fraction among those exposed to early sugar rationing.
