Equally Effective Dual Therapy Combinations for Hypertension in Indian Patients: Insights from a Landmark Randomized Trial

Highlight

• Three commonly recommended antihypertensive dual combination therapies were compared in a large randomized trial in India.
• All three combinations—amlodipine-perindopril, perindopril-indapamide, and amlodipine-indapamide—achieved approximately 14 mmHg reductions in ambulatory systolic BP at 6 months.
• Hypertension control rates were similar and high (~70%) across all treatment arms with minimal safety concerns.
• These data fill a critical evidence gap for optimizing combination therapy in South Asian hypertensive patients.

Study Background and Disease Burden