Divergent Roles of IL-12p40 and IL-18 in Severe Fibrosing Chronic Graft-versus-Host Disease: Implications for Immunity and Post-Transplant Outcomes
IL-18Allogeneic Hematopoietic Stem Cell TransplantationIL-12p40chronic graft-versus-host diseaseimmunity
Highlight
- IL-12p40 and IL-18 serum levels are elevated at cGvHD onset in patients who later develop severe fibrosing forms.
- Despite both being IFNγ-related cytokines, IL-12p40 associates with reduced relapse and better survival, whereas IL-18 correlates with increased risk of severe cGvHD and worse outcomes.
- The divergent roles suggest different immunological pathways mediating fibrosis, relapse control, and response to immunosuppressive therapy.
Study Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.