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Combined Nicotinamide Riboside and Home-Based Exercise Improved Peak VO2 Safely in Friedreich’s Ataxia

MedXY Editorial Team•May 3, 2026•Neurology
exercise therapyFriedreich's ataxianicotinamide ribosidepeak VO2

Highlights

In this single-centre, 2 × 2 factorial, randomised phase 2 trial, the combination of nicotinamide riboside and individualized home-based exercise improved peak oxygen consumption over 12 weeks in patients with Friedreich’s ataxia compared with placebo and no exercise.

The adjusted between-group difference in change in peak VO2 for combination therapy versus control was 0.21 L/min (95% CI 0.05 to 0.36; padjusted=0.0299), meeting the study’s prespecified efficacy threshold in stage 1 analysis.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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