Clinical Applications of Ergothioneine: Advances in Antioxidant, Anti-Aging, and Exercise-Enhancing Effects
Highlights
- Ergothioneine is bioavailable in humans, predominantly via mushroom consumption, and shows potential modulation of oxidative stress and lipid metabolism.
- Clinical studies reveal ergothioneine contributes to antioxidant defenses by regulating nitric oxide and thiol redox balance, though anti-inflammatory effects are inconsistent.
- Current evidence on its role in exercise-induced muscle damage indicates antioxidant benefits with limited impact on inflammation, suggesting a nuanced mechanism of action.
- Data underpinning anti-aging effects remain preliminary, requiring longitudinal and mechanistic clinical studies to establish therapeutic relevance.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.