Causal Insights Into Hidradenitis Suppurativa: Mendelian Randomization Evidence Linking BMI, Inflammatory Bowel Disease, and Smoking
Highlights
- Mendelian randomization (MR) confirms causal impact of increased body mass index (BMI) and inflammatory bowel disease (IBD) on the risk of hidradenitis suppurativa (HS).
- Smoking shows initial genetic evidence of causality but lacks consistent support in sensitivity MR analyses.
- Genetic correlations link HS with multiple inflammatory disorders, including psoriasis and rheumatoid arthritis, while systemic sclerosis shows no causality with HS risk.
- These genetic insights offer clinicians evidence to advocate lifestyle modification and target systemic inflammation in HS management.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.