Mendelian randomization (MR) confirms causal impact of increased body mass index (BMI) and inflammatory bowel disease (IBD) on the risk of hidradenitis suppurativa (HS).
Smoking shows initial genetic evidence of causality but lacks consistent support in sensitivity MR analyses.
Genetic correlations link HS with multiple inflammatory disorders, including psoriasis and rheumatoid arthritis, while systemic sclerosis shows no causality with HS risk.
These genetic insights offer clinicians evidence to advocate lifestyle modification and target systemic inflammation in HS management.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.