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Tailoring Misoprostol Dosing for Labor Induction: The Influence of BMI and Administration Route
newsobesityBMI

Tailoring Misoprostol Dosing for Labor Induction: The Influence of BMI and Administration Route

By MedXY|Aug 25, 2026

Obesity increases the number of misoprostol doses needed for active labor during induction, with buccal dosing requiring more doses than vaginal, highlighting implications for individualized labor management.

Steroids, Stress, and Body Mass Index Interact to Accelerate Female Pubertal Development
Diabetes & EndocrinologyBMIendocrinology

Steroids, Stress, and Body Mass Index Interact to Accelerate Female Pubertal Development

By MedXY|Aug 19, 2026

Elevated glucocorticoids, androgens, and progesterone metabolites, combined with high BMI and stress, accelerate the onset of puberty in girls, particularly breast development (thelarche).

Beyond BMI: How Waist Circumference and Waist-to-Hip Ratio Enhance Cardiovascular Risk Prediction
CardiologyBMIcardiovascular risk

Beyond BMI: How Waist Circumference and Waist-to-Hip Ratio Enhance Cardiovascular Risk Prediction

By MedXY|Aug 13, 2026

This analysis reveals that waist circumference and waist-to-hip ratio improve cardiovascular risk classification beyond BMI, identifying individuals with hidden risk and refining prognostic assessments across multiple cardiovascular outcome

New Obesity Definitions Reclassify Many MASLD Patients but Do Not Improve Liver Risk Prediction
GastroenterologyMASLDliver-related events

New Obesity Definitions Reclassify Many MASLD Patients but Do Not Improve Liver Risk Prediction

By MedXY|Jul 28, 2026

New obesity definitions reclassify many MASLD patients as obese but do not improve prediction of liver-related events over BMI alone, according to a multinational cohort study.

Oral Semaglutide and Cardiovascular Benefits in the SOUL Trial: Impact of Baseline and Changes in HbA1c and BMI on Clinical Outcomes
CardiologyBMIcardiovascular risk

Oral Semaglutide and Cardiovascular Benefits in the SOUL Trial: Impact of Baseline and Changes in HbA1c and BMI on Clinical Outcomes

By MedXY|Jul 22, 2026

This analysis of the SOUL trial shows oral semaglutide reduces major cardiovascular events, with greater benefits linked to higher baseline HbA1c and larger HbA1c reductions, while BMI changes did not significantly affect outcomes.

Body Mass Index and Nutritional Status With Immunotherapy Response in Head and Neck Cancer
newsBMIhead and neck cancer

Body Mass Index and Nutritional Status With Immunotherapy Response in Head and Neck Cancer

By MedXY|May 20, 2026

In advanced head and neck squamous cell carcinoma, pretreatment weight loss and low prognostic nutritional index were linked to shorter progression-free survival after immunotherapy, while baseline BMI was not predictive.

Beyond Height Velocity: Longitudinal Impact of Long-Acting Growth Hormone on Body Mass Index in Pediatric Growth Hormone Deficiency
Clinical UpdatesBMIGHD

Beyond Height Velocity: Longitudinal Impact of Long-Acting Growth Hormone on Body Mass Index in Pediatric Growth Hormone Deficiency

By MedXY|Mar 11, 2026

This meta-analysis reveals that long-acting growth hormone (LAGH) is associated with a significant increase in BMI SD scores during the first year of treatment and upon switching from daily GH, suggesting a distinct metabolic profile compar

Causal Insights Into Hidradenitis Suppurativa: Mendelian Randomization Evidence Linking BMI, Inflammatory Bowel Disease, and Smoking
Clinical UpdatesBMIhidradenitis suppurativa

Causal Insights Into Hidradenitis Suppurativa: Mendelian Randomization Evidence Linking BMI, Inflammatory Bowel Disease, and Smoking

By MedXY|Dec 24, 2025

Recent Mendelian randomization analyses demonstrate causal effects of increased BMI and inflammatory bowel disease on hidradenitis suppurativa risk, elucidating modifiable contributions beyond genetic correlations with psoriasis and systemi

Underweight in Type 2 Diabetes Raises Cardiovascular Risk — Severe Leanness Carries Greater Risk Than Obesity
CardiologyBMIcardiovascular disease

Underweight in Type 2 Diabetes Raises Cardiovascular Risk — Severe Leanness Carries Greater Risk Than Obesity

By MedXY|Dec 2, 2025

A nationwide Korean cohort found that underweight patients with Type 2 diabetes—especially those with severe underweight—have higher cardiovascular risk than normal-weight and even some obese patients, underscoring the need to screen and ma

T2 Mapping Detects BMI-Linked Cartilage Changes and Lateral Compartment Signal Differences in Population-Based Knee OA
newsBMIknee osteoarthritis

T2 Mapping Detects BMI-Linked Cartilage Changes and Lateral Compartment Signal Differences in Population-Based Knee OA

By MedXY|Nov 2, 2025

In a large population-based sample, cartilage T2 relaxation times correlated with BMI and were higher in knees with MRI-defined osteoarthritis, particularly in lateral cartilage subregions; T2 did not reflect patient-reported symptoms.

Partitioning Knee Osteoarthritis Genetic Risk by BMI Association Clarifies Prediction and Mechanisms
newsBMIgenetics

Partitioning Knee Osteoarthritis Genetic Risk by BMI Association Clarifies Prediction and Mechanisms

By MedXY|Nov 2, 2025

Partitioning a knee osteoarthritis polygenic score into BMI-associated and BMI-independent components clarifies genetic contributions, improves interpretability, and offers a path to tailored prediction and prevention.

Revisiting Obesity Classification: Insights from a Population-Based Survey in Peru Using New Clinical Frameworks
Diabetes & EndocrinologyBMIclinical obesity

Revisiting Obesity Classification: Insights from a Population-Based Survey in Peru Using New Clinical Frameworks

By MedXY|Oct 19, 2025

This review examines a landmark Peruvian study applying new obesity definitions that incorporate clinical dysfunction and adiposity measures beyond BMI, revealing substantial underdiagnosis with traditional approaches and ethnic variation i

Once-Weekly Semaglutide 2.4 mg for Obesity Management in Asian Adults: Efficacy, Safety, and Policy Insights from the STEP 11 Trial
Diabetes & EndocrinologyAsian PopulationBMI

Once-Weekly Semaglutide 2.4 mg for Obesity Management in Asian Adults: Efficacy, Safety, and Policy Insights from the STEP 11 Trial

By MedXY|Oct 6, 2025

The STEP 11 trial demonstrates that once-weekly semaglutide 2.4 mg significantly reduces bodyweight in Asian adults with obesity (BMI ≥25 kg/m²), supporting its safety and guideline inclusion in these populations with unique BMI thresholds.

Tirzepatide’s Role in Obesity-Related HFpEF: Influence of BMI, Central Adiposity, and Weight Loss from the SUMMIT Trial
CardiologyBMICentral Adiposity

Tirzepatide’s Role in Obesity-Related HFpEF: Influence of BMI, Central Adiposity, and Weight Loss from the SUMMIT Trial

By MedXY|Oct 3, 2025

Tirzepatide reduces heart failure risk in obese HFpEF patients regardless of BMI or central adiposity, with greater benefits on exercise capacity and symptom scores associated with higher BMI and weight loss.

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