Behavioral Diet Therapy Achieves Superior Postprandial Glycemic Control Over Gastric Bypass Despite Equivalent Weight Loss

Highlights

In patients with obesity and type 2 diabetes, achieving a 20% weight loss through behavioral diet therapy (BDT) results in a significantly greater reduction in postprandial plasma glucose area under the curve (AUC) compared to the same degree of weight loss achieved via Roux-en-Y gastric bypass (RYGB).

While both weight loss interventions effectively reduce endogenous glucose production, the physiological drivers of glucose disposal differ markedly between the two modalities.