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Antibiotic Exposure Linked to Shorter Biologic Survival in Psoriasis: A Large French Cohort Suggests a Dose–Response Relationship

MedXY Editorial Team•Nov 17, 2025•Dermatology
Antibioticsbiologicsmicrobiomepsoriasis

Highlight

– In a French nationwide cohort of 36,129 adults initiating biologics for psoriasis, antibiotic exposure before or during follow-up was associated with a higher risk of discontinuing or switching the initial biologic (weighted HR 1.12; 95% CI 1.08–1.16).

– A dose–response effect was observed: patients with ≥2 antibiotic dispensations in a 6‑month window had a higher hazard of biologic discontinuation (weighted HR 1.29; 95% CI 1.24–1.35).

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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