– In a French nationwide cohort of 36,129 adults initiating biologics for psoriasis, antibiotic exposure before or during follow-up was associated with a higher risk of discontinuing or switching the initial biologic (weighted HR 1.12; 95% CI 1.08–1.16).
– A dose–response effect was observed: patients with ≥2 antibiotic dispensations in a 6‑month window had a higher hazard of biologic discontinuation (weighted HR 1.29; 95% CI 1.24–1.35).
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