Weekly Amylin Agonist Eloralintide Produces 10–21% Weight Loss at 48 Weeks in Phase 2 Trial
Highlights
– Weekly subcutaneous eloralintide (an amylin receptor agonist) produced dose‑dependent mean weight loss of 9.4% to 20.9% at 48 weeks versus 0.4% with placebo in a randomized phase 2 trial (n=263).
– Dose‑escalation strategies (eg, 6→9 mg) were associated with large weight loss (≈19.9%) and lower discontinuation due to adverse effects compared with forced higher‑dose starts.
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