Highlights
The age-adjusted D-dimer cutoff (age × 10 µg/L for patients 50 years or older) has been prospectively validated to safely rule out deep vein thrombosis (DVT) in outpatients. In the multicenter ADJUST-DVT study, no symptomatic venous thromboembolic events were identified during a 3-month follow-up in patients ruled out using the adjusted threshold. This diagnostic strategy significantly increases the proportion of elderly patients in whom DVT can be ruled out without the need for leg compression ultrasonography, tripling the diagnostic yield in those aged 75 and older.
