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This article reviews advances in liver xenotransplantation using genetically modified porcine organs as a bridging strategy for acute liver failure, highlighting recent clinical progress, challenges, and future directions.
CRISPR-engineered GGTA1/B4GALNT2/SLA-DR knockout pigs remained healthy, screened negative for 55 zoonotic pathogens, and supported long-term renal xenograft function in rhesus monkeys when preformed anti-SLA antibodies were absent.
Phân tích đa chế độ của hai quả tim lợn đã được chỉnh sửa gen 10 gen được ghép vào người đã chết não cho thấy sự viêm vi mạch bẩm sinh sớm với kích hoạt nội mô và hồ sơ phân tử phù hợp với tổn thương do kháng thể mặc dù không có C4d trong m
Multimodal analysis of two 10-gene–edited pig hearts transplanted into brain-dead human recipients revealed early innate microvascular inflammation with endothelial activation and a molecular profile consistent with antibody-mediated injury
The International Xenotransplantation Association (IXA) 2025 position paper offers evidence-based recommendations for initial clinical trials of genetically engineered porcine kidney transplants for end-stage renal disease, focusing on dono
This landmark study reports the first successful genetically engineered pig auxiliary liver transplanted into a living human, revealing critical insights on immunological compatibility and post-transplant complications, advancing liver xeno
Recent advances in genetically modified pig-to-human organ transplantation offer promising solutions for acute liver failure, bridging critical gaps in organ availability and raising important ethical and regulatory considerations.
Since the landmark combined liver–kidney transplant in 1984, advances in surgical techniques, immunosuppression, and donor allocation have revolutionized care for patients with dual organ failure. Emerging innovations, including gene-edited
