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Diabetes & Endocrinology

Petrelintide: A Promising Human Amylin Analogue for Long-Term Obesity Management

Petrelintide, a novel once-weekly human amylin analogue, demonstrates significant bodyweight reduction versus placebo in adults with obesity, with favorable gastrointestinal tolerability, supporting its potential as a long-term obesity ther

Oct 4, 2026Sign in to read
Diabetes & Endocrinology

Time-Restricted Eating in Adults With Type 1 Diabetes: Safety and Glycemic Benefits Without Significant Weight Loss

A 6-month randomized controlled trial found that time-restricted eating (TRE) in adults with type 1 diabetes is safe and improves HbA1c levels but does not significantly reduce body weight compared to calorie restriction or no intervention.

Aug 17, 2026
Clinical Updates

Efficacy and Safety of Once-Weekly Semaglutide 2.4 mg in Chinese Adults with Overweight or Obesity: Insights from the STEP 12 Trial and Regional Evidence

This review synthesizes evidence from the STEP 12 trial and related studies demonstrating that once-weekly semaglutide 2.4 mg significantly reduces bodyweight and improves cardiometabolic outcomes in Chinese adults with overweight or obesit

Aug 11, 2026Sign in to read
Diabetes & Endocrinology

Efficacy and Safety of Cagrilintide-Semaglutide Combination vs Semaglutide Alone for Weight Management in East Asian Adults with Overweight/Obesity: REDEFINE 5 Trial

Phase 3a trial in Japan/Taiwan shows cagrilintide-semaglutide combination delivers superior weight loss (18.4%) versus semaglutide alone (11.9%) in adults with overweight/obesity ± type 2 diabetes, with comparable safety profiles dominated

Apr 22, 2026
General Surgery

Preoperative Total Diet Replacement Safely Reduces Morbidity Risk and Preserves Muscle Mass in Colorectal Cancer Surgery

The CARE feasibility trial demonstrates that a preoperative low-energy total diet replacement program is safe and effective for colorectal cancer patients with excess weight. Significant weight loss was achieved without compromising lean mu

Dec 22, 2025
Clinical Updates

Planetary Health Diet and Cardiometabolic Risk Reduction in Women with Gestational Diabetes: An Evidence-Based Review

This review synthesizes evidence linking adherence to the Planetary Health Diet with reduced risks of myocardial infarction, type 2 diabetes, and improved weight management in women post-gestational diabetes, highlighting BMI’s mediat

Dec 15, 2025Sign in to read
Diabetes & Endocrinology

Time-Restricted Eating: Separating Facts from Fad in Metabolic Health

A landmark study challenges the metabolic benefits of time-restricted eating, revealing its effects primarily stem from calorie reduction rather than meal timing, while highlighting its influence on the biological clock.

Nov 7, 2025
Cardiology

Integrating Obesity Management into Cardiac Rehabilitation: Challenges, Evidence, and Future Directions

Obesity management in cardiac rehabilitation (CR) is underutilized despite its cardiovascular benefits. This review explores the evidence, complexities, patient perspectives, and healthcare provider attitudes, emphasizing tailored strategie

Oct 24, 2025Sign in to read
Diabetes & Endocrinology

Enhanced Weight Reduction with Once-Weekly Semaglutide 7.2 mg in Obesity Management: Insights from the STEP UP Phase 3b Trial

The STEP UP trial demonstrates that once-weekly semaglutide 7.2 mg significantly improves weight loss outcomes versus 2.4 mg and placebo in adults with obesity, with a manageable safety profile.

Oct 18, 2025
Diabetes & Endocrinology

Patterns and Predictors of GLP-1 Agonist Use After Bariatric Surgery in US Adults

A large US cohort study reveals that 14% of bariatric surgery patients start GLP-1 receptor agonists postoperatively, with higher use seen among women, sleeve gastrectomy recipients, and those with greater BMI regain.

Oct 10, 2025
Diabetes & Endocrinology

Oral Semaglutide 25 mg: A New Oral Therapeutic Option for Weight Management in Overweight and Obese Adults

Oral semaglutide 25 mg once daily significantly reduces body weight versus placebo and improves physical function in adults with overweight or obesity, offering an alternative to injectable formulations.

Sep 17, 2025Sign in to read
Clinical Updates

Evaluating Peer Coaching for Weight Management in Primary Care: Insights from a VA-Based Cluster Randomized Clinical Trial

A cluster randomized trial in veterans assessed peer coaching for weight management, showing improved program attendance but no significant 12-month weight loss difference versus enhanced usual care.

Sep 13, 2025
Family Medicine & Nutrition

10 Habits That Cancer Cells Fear: Building Your Body’s Natural Defense

Explore ten evidence-based lifestyle habits that significantly reduce cancer risk and empower your body’s natural defenses against cancer development.

Sep 8, 2025
Diabetes & Endocrinology

Cagrilintide-Semaglutide Combination Shows Promising Efficacy for Weight and Glycemic Control in Adults with Type 2 Diabetes and Obesity

A 68-week phase 3a trial demonstrates that once-weekly cagrilintide-semaglutide significantly reduces body weight and improves glycemic control compared to placebo in adults with overweight or obesity and type 2 diabetes, with good tolerabi

Sep 7, 2025
Cardiology

The Powerful Benefits of Going to Bed Earlier: Weight, Mood, and Heart Health

Shifting your bedtime earlier by just one hour can aid weight management, reduce depression risk, and protect your heart, according to recent scientific findings.

Sep 3, 2025Sign in to read
Diabetes & Endocrinology

Efficacy and Safety of Ecnoglutide, a cAMP-Biased GLP-1 Receptor Agonist, in Weight Management for Overweight and Obese Adults: Insights from a Phase 3 Multicentre Randomised Trial

This review synthesizes evidence from a multicentre, phase 3 trial on ecnoglutide, demonstrating significant and sustained weight loss in overweight/obese adults without diabetes, with a favorable safety profile, supporting its clinical use

Aug 27, 2025
Family Medicine & Nutrition

Late-Night Snacking vs. Going to Bed Hungry: Which is More Harmful?

Exploring the health impacts of eating late-night snacks versus sleeping hungry, this article dispels myths about weight gain, highlights risks, and offers evidence-based guidelines for healthy eating habits before bedtime.

Aug 25, 2025
Family Medicine & Nutrition

Exercising for 20 Minutes Can Counteract the Harm of Sleep Deprivation

Moderate exercise for 20 minutes daily can reduce inflammation caused by lack of sleep and improve cardiovascular health, immunity, weight control, and mental well-being.

Aug 8, 2025
Family Medicine & Nutrition

The Top 10 Fruits for Fat Loss: Science, Myths, and Smart Eating

Discover the ten most recognized fat-loss fruits, their science-backed benefits, and practical tips to incorporate them into your diet for healthy weight management.

Aug 6, 2025
Family Medicine & Nutrition

How High-Fiber Diets and Supplements Can Improve Health for Patients With Obesity

High-fiber diets and supplements can aid weight management, improve metabolic health, and reduce obesity-related risks by enhancing digestion, promoting satiety, and regulating blood sugar levels.

Aug 6, 2025
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