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Clinical Updates

Tirzepatide Influences Muscle Composition Favorably Amid Weight Loss in Type 2 Diabetes: Insights from SURPASS-3 MRI Substudy

In type 2 diabetes patients, tirzepatide treatment led to significant reductions in muscle fat infiltration and adaptive decreases in muscle volume over 52 weeks, suggesting beneficial effects on muscle health concurrent with weight loss.

Sep 19, 2025
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Family Medicine & Nutrition

From Plate to Progress: Five Scientifically Proven Diets to Help Manage Obesity Effectively

Explore five scientifically supported dietary patterns that aid effective weight loss for individuals struggling with obesity, emphasizing balanced nutrition and sustainable lifestyle changes.

Sep 18, 2025
Clinical Updates

Optimizing Metabolic and Physical Health in Obese Older Adults: Impact of Exercise Modalities on Insulin Secretion, CNTF, and IGF-1 During Weight Loss

Combining aerobic and resistance exercise with diet-induced weight loss in obese older adults significantly improves insulin secretion, preserves CNTFRα levels, and increases IGF-1, enhancing metabolic and physical function.

Sep 17, 2025
Diabetes & Endocrinology

Oral Semaglutide Demonstrates Significant Weight Loss Efficacy in East Asian Adults with Overweight or Obesity: Insights from the OASIS 2 Trial

The OASIS 2 trial shows oral semaglutide 50 mg significantly reduces body weight in East Asian adults with overweight or obesity, with or without type 2 diabetes, offering a promising therapeutic option with manageable safety profile.

Sep 7, 2025Sign in to read
Diabetes & Endocrinology

Once-Weekly Semaglutide 2.4 mg for Obesity Management in Asian Adults: Efficacy, Safety, and Policy Insights from the STEP 11 Trial

The STEP 11 trial demonstrates that once-weekly semaglutide 2.4 mg significantly reduces bodyweight in Asian adults with obesity (BMI ≥25 kg/m²), supporting its safety and guideline inclusion in these populations with unique BMI thresholds.

Sep 7, 2025
Clinical Updates

Advancing Obesity Management: Once-Monthly Maridebart Cafraglutide Demonstrates Significant Weight Loss Efficacy

Maridebart cafraglutide, a novel once-monthly peptide-antibody conjugate, significantly reduces body weight in individuals with obesity, with and without type 2 diabetes, offering a new therapeutic option based on phase 2 trial results.

Sep 7, 2025
Diabetes & Endocrinology

CagriSema: A Breakthrough Combination Therapy for Weight Loss in Adults with Overweight or Obesity

A phase 3a trial shows coadministered cagrilintide and semaglutide (CagriSema) significantly reduce body weight up to 20.4% over 68 weeks in adults with overweight or obesity, with manageable side effects, offering a promising new option fo

Aug 28, 2025
Cardiology

Morning or Evening? The Science Behind The Best Time to Exercise for Weight Loss and Muscle Growth

Discover how exercising at 7 AM or 7 PM can boost weight loss and muscle growth, tailored to your body’s rhythms and lifestyle.

Aug 22, 2025
news

Weight Reduction Before Conception: Enhancing Fertility and Reducing Pregnancy Complications in Overweight and Obese Women

A 10%-25% preconception weight loss in overweight or obese women modestly increases pregnancy likelihood and significantly lowers gestational diabetes and hypertensive complication risks, improving maternal and neonatal outcomes.

Aug 19, 2025Sign in to read
Diabetes & Endocrinology

Microbiota-Mediated Weight Loss: Insights from the WLM3P Multicomponent Program in Obesity

The WLM3P weight loss program significantly remodels gut microbiota, enriching beneficial bacteria such as Faecalibacterium, which associates with improved fat and visceral fat loss in adults with obesity compared to standard low-carb diets

Aug 18, 2025
Family Medicine & Nutrition

Comparative Impact of 4:3 Intermittent Fasting Versus Daily Caloric Restriction on Eating Behaviors and Appetite Hormones Over 12 Months

A 12-month trial reveals 4:3 intermittent fasting improves binge and uncontrolled eating behaviors more than daily caloric restriction, correlating with greater weight loss, while appetite hormone changes do not differ significantly between

Aug 18, 2025
Diabetes & Endocrinology

Top 10 Weight Loss Pitfalls and How to Avoid Them: A Science-Based Guide

Uncover the ten most common weight loss misconceptions and pitfalls, and learn scientifically grounded practices to achieve sustainable, healthy fat loss.

Aug 17, 2025
Family Medicine & Nutrition

5 Hidden Weight Gain Traps Sabotaging Your Diet — And How to Avoid Them

Discover five common pitfalls that secretly lead to weight gain during dieting, and learn science-backed strategies for healthy, sustainable weight loss.

Aug 17, 2025
Diabetes & Endocrinology

Debunking Weight Loss Myths: Avoid These Pitfalls for More Effective and Healthy Weight Loss

This article explores common weight loss misconceptions, offering scientific insights and strategies for safe and sustainable fat loss.

Aug 17, 2025Sign in to read
Cardiology

Tirzepatide’s Role in Obesity-Related HFpEF: Influence of BMI, Central Adiposity, and Weight Loss from the SUMMIT Trial

Tirzepatide reduces heart failure risk in obese HFpEF patients regardless of BMI or central adiposity, with greater benefits on exercise capacity and symptom scores associated with higher BMI and weight loss.

Aug 17, 2025
Cardiology

Effect of a Ketogenic Diet, Time-Restricted Eating, or Alternate-Day Fasting on Weight Loss in Adults with Obesity: A Randomized Clinical Trial

This clinical trial compares the weight loss effects of ketogenic diet, time-restricted eating, and alternate-day fasting against a Mediterranean diet in adults with obesity over three months.

Aug 8, 2025
Clinical Updates

Intermittent Fasting for Weight Loss in Night Shift Workers: A Three-Arm Superiority Randomised Clinical Trial

This clinical trial compared two modified intermittent fasting strategies to continuous energy restriction for weight loss and insulin resistance improvements in night shift workers, finding no significant differences but overall health ben

Aug 8, 2025
Family Medicine & Nutrition

Is Jackfruit High in Calories? Can You Eat Jackfruit While Dieting?

This article explores the calorie content and nutritional benefits of jackfruit, discussing whether it is suitable for consumption during weight loss and how to incorporate it sensibly into a diet.

Aug 6, 2025
Family Medicine & Nutrition

Top 5 Lowest-Calorie Fruits Recommended for Healthy Weight Loss

Discover the five fruits with the lowest calorie content, ideal for weight loss and healthy eating. Learn their nutritional benefits and how to incorporate them into your diet effectively.

Aug 6, 2025Sign in to read
Family Medicine & Nutrition

Stress and Weight: Does Pressure Make You Gain or Lose Pounds?

Explore how stress impacts body weight, causing some to gain while others lose pounds due to hormonal and neural responses.

Aug 5, 2025
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