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Kynurenic acid (KYNA) reduction in the gut correlates with worse poststroke outcomes. Supplementation activates a gut-brain neural circuit via GPR35 and the vagus nerve, promoting neuroprotection and functional recovery after ischemic strok
This article explores the vital role of the vagus nerve in modulating myocardial infarction outcomes through autonomic regulation, reflex pathways, and cardioprotective mechanisms, highlighting translational potential from experimental mode
A 3-month RCT demonstrates that multi-species probiotic supplementation improves vagal nerve function, gut microbiome composition, and sleep quality in patients with major depression, suggesting novel gut-brain axis interventions.
Recent research reveals that pathological tau can propagate from the brain to the colon through the vagal efferent pathway in Alzheimer’s disease, supporting a novel brain-to-gut axis involvement in disease progression and gut functio
