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The ADMIRE CD II Phase 3 trial failed to show a significant benefit of darvadstrocel over placebo for complex perianal fistulas in Crohn’s disease, primarily due to an unexpectedly high remission rate in the placebo-controlled surgica
This phase 1 study evaluates the safety of placenta-derived mesenchymal stem cells (PMSCs) seeded on an extracellular matrix for in-utero repair of myelomeningocele, demonstrating successful surgical outcomes and no cell-related adverse eve
This meta-analysis evaluates stem cell therapy combined with mechanical support for avascular necrosis of the femoral head, highlighting modest improvements in function and delayed disease progression compared to stem cells alone.
Zimislecel, an allogeneic stem cell-derived islet-cell therapy, demonstrates promising safety and efficacy for type 1 diabetes, restoring physiologic islet function and enabling insulin independence in a phase 1-2 trial.
A phase II trial finds that intrathecal autologous bone marrow mononuclear cell therapy combined with education significantly improves core symptoms and adaptive behaviors in young children with ASD compared to education alone.
Recent research highlights stem cell therapy as a promising method for improving fertility in women facing ovarian failure, showing significant oocyte activation and pregnancy rates.
