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MedXY AI/MedXY News/Tag: sirolimus
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Belatacept and Sirolimus Show Promise as Safer Immunosuppression in Islet Transplantation for Type 1 Diabetes
Diabetes & Endocrinologyimmunosuppressiontype 1 diabetes

Belatacept and Sirolimus Show Promise as Safer Immunosuppression in Islet Transplantation for Type 1 Diabetes

By MedXY|Aug 18, 2026

A multi-centre phase 2 study demonstrates that belatacept combined with sirolimus achieves superior islet transplant outcomes with better renal preservation compared to conventional tacrolimus-based therapy in type 1 diabetes patients.

SARC031 Trial: Why Combined MEK and mTOR Inhibition Failed to Translate from Mice to Men in MPNST
newsoncologyselumetinib

SARC031 Trial: Why Combined MEK and mTOR Inhibition Failed to Translate from Mice to Men in MPNST

By MedXY|Jan 13, 2026

The SARC031 Phase 2 trial evaluated selumetinib and sirolimus for advanced MPNST. Despite strong preclinical rationale, the combination showed minimal clinical benefit, though correlative studies on cfDNA and PET imaging offer vital insight

Post‑transplant Cyclophosphamide with Sirolimus/Cyclosporine Dramatically Lowers Chronic GVHD After Unrelated Donor PBSC Transplant Without Raising Relapse Risk
Hematology-OncologyGVHDposttransplant cyclophosphamide

Post‑transplant Cyclophosphamide with Sirolimus/Cyclosporine Dramatically Lowers Chronic GVHD After Unrelated Donor PBSC Transplant Without Raising Relapse Risk

By MedXY|Dec 10, 2025

In a randomized Phase II trial, replacing MMF with post‑transplant cyclophosphamide (PTCy) alongside sirolimus and cyclosporine in unrelated donor PBSC transplants markedly lowered chronic GVHD and improved 1‑year chronic GVHD‑free relapse‑

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