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This study reveals that TL1A-activated CD4+ T cells drive distinct cellular and molecular changes in the rectal mucosa of Crohn’s disease patients with perianal fistulising disease (PFD), highlighting a novel TL1A-LTα1β2/IL-22 axis in
Single-cell transcriptomic profiling of ide-cel CAR-T products reveals that intrinsic NF-κB signaling in CD4 CAR-T cells correlates with durable remission in relapsed/refractory multiple myeloma, marking T-cell fitness and potential therape
Single-cell RNA sequencing of pancreatic islets reveals distinct molecular signatures linked to specific clinical subtypes of type 2 diabetes, highlighting the heterogeneous pathophysiology and providing potential subtype-specific therapeut
Spatially distinct macrophage subsets interact with heterogeneous myofibroblast populations in lupus nephritis, driving maladaptive fibrosis and chronic kidney injury. Identifying these fibroinflammatory circuits offers promising targets fo
Single-cell analysis of carotid plaques identifies four macrophage subtypes, with lipid-associated macrophage markers PLIN2 and TREM1 predicting secondary major adverse cardiovascular events after endarterectomy.
Single-cell RNA sequencing suggests that childhood poverty exposure is associated with steroid-resistance signatures in leukemic blasts and adverse immune remodeling at diagnosis in standard-risk B-ALL.