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This analysis of the Phase 3 ARISE-HF trial explores sex differences in diabetic cardiomyopathy (DbCM) and the efficacy of AT-001. While women presented with worse exercise capacity and health status at baseline, the novel aldose reductase
A 13-year national cohort shows that combined healthy lifestyles and favourable social determinants substantially increase years lived independently; men gain more from behavioural change while women gain more from improved social condition
New animal research links oral microplastic exposure to dramatic increases in arterial plaque—especially in males—by injuring endothelial cells and provoking inflammation and oxidative stress.
In a population-based Alberta cohort, women with incident stage 5 CKD lost the usual female survival advantage: younger women had substantially higher excess mortality than men and were less likely to receive transplants or dialysis, indepe
In vivo awake recordings in transgenic mice show APOE ε4 reduces neuronal excitability in the anterior olfactory nucleus (AON); adult females are more excitable than males (a sex difference lost with aging), while aging amplifies network os
This Swedish population-based study highlights how suicide risk indicators vary by sex and age, showing males and older adults exhibit fewer, but often higher absolute risk indicators, underscoring the need for tailored suicide prevention s
This study explores how biological sex influences CRS diagnosis and inflammatory biomarkers, revealing sex-specific patterns that could inform personalized treatment.
The REBOOT trial reveals a sex-specific differential effect of beta-blockers after MI, showing increased harm in women with preserved LVEF, challenging current guideline recommendations.
Desmoplakin gene variants confer a higher risk and penetrance of dilated cardiomyopathy in females, contrasting with male-predominant risks from other genes like TTN. This discovery underscores sex-specific mechanisms in DCM susceptibility
COVID-19 accelerates vascular aging by approximately 5 years, disproportionately affecting women, with vaccination conferring protection primarily in females, highlighting sex-specific immunological responses and long-term vascular risks.
AI-based quantitative CT analysis demonstrates that coronary plaque features, while more prevalent in men, confer a disproportionately higher relative risk of major adverse cardiovascular events in women, highlighting the need for sex-speci
A study from the Framingham Heart Study cohort reveals that traumatic brain injury (TBI) is linked to significant brain volume loss in older women but not men, highlighting sex-specific vulnerability to neurodegeneration post-TBI.
