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This study reveals that combining stress hyperglycemia ratio and glucose variability significantly improves mortality prediction in sepsis, with risk patterns varying significantly based on a patient’s baseline metabolic status (Norma
A large-scale study of 35,691 sepsis patients reveals that clinical subtypes are highly dynamic, with 82% of patients changing categories within 48 hours. This classification uncertainty significantly impacts treatment response and long-ter
The RETRO-MENINGO study of 654 adults reveals that hemodynamic presentations of invasive meningococcal disease carry a five-fold higher mortality risk than neurological forms. Early parenteral antibiotic administration remains the most crit
Large-scale cohort and prospective data reveal that monocyte HLA-DR expression is a dynamic predictor of ICU-acquired infections and mortality, offering a roadmap for personalized immunostimulant therapy in septic shock and transplant patie
A large-scale study of over 300,000 ANZ ICU patients reveals that sepsis mortality plummeted from 28% to 11% between 2000 and 2020, followed by a concerning 0.9% annual increase through 2023, highlighting both clinical triumphs and emerging
A large-scale target trial emulation demonstrates that de-escalating anti-MRSA and anti-pseudomonal therapy on day 4 of sepsis treatment is safe, associated with fewer antibiotic days, and leads to shorter hospital stays compared to continu
In a multicenter Korean sepsis cohort, early RBC transfusions were frequent and driven by illness severity. No overall 60‑day mortality difference was seen after propensity matching, but transfusion was associated with harm at hemoglobin ≥1
The ImmunoSep randomized trial found that biomarker-guided immunotherapy (anakinra for macrophage activation‑like syndrome; interferon‑γ for sepsis‑induced immunoparalysis) improved organ dysfunction by day 9 versus placebo, though 28‑day m
This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.
This study evaluates factors influencing vasopressor route choice in sepsis and demonstrates low complication rates associated with peripheral administration, supporting its safety in early resuscitation.
This article reviews findings from the CLOVERS trial analyzing endothelial glycocalyx degradation in sepsis, demonstrating its strong association with mortality but showing no impact of liberal versus restrictive fluid resuscitation strateg
This trial demonstrates that a ketogenic diet safely induces stable ketosis in sepsis patients, improving metabolic parameters and immune regulation without adverse effects, suggesting potential benefits for sepsis-related organ dysfunction
