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Unraveling Right Ventricular Failure in PH-HFpEF: Integrative Insights from Vascular Mechanics and Transcriptomics
CardiologyHuyết Áp PhổiRight Ventricular Failure

Unraveling Right Ventricular Failure in PH-HFpEF: Integrative Insights from Vascular Mechanics and Transcriptomics

By MedXY|Aug 25, 2026

This study integrates vascular mechanics, advanced imaging, and myocardial transcriptomics to elucidate the mechanisms of right ventricular failure in pulmonary hypertension secondary to heart failure with preserved ejection fraction, uncov

From Compensation to Collapse: How Cardiac Myofibroblasts and UCP2 Genetic Variants Dictate Right Ventricular Fate in PAH
CardiologyMyofibroblastspulmonary arterial hypertension

From Compensation to Collapse: How Cardiac Myofibroblasts and UCP2 Genetic Variants Dictate Right Ventricular Fate in PAH

By MedXY|Mar 9, 2026

This study identifies the transition of cardiac fibroblasts to myofibroblasts as a critical driver of right ventricular failure in PAH, highlighting the role of UCP2 deficiency and the rs659366 SNP as key clinical indicators of decompensati

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