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Early Exclusive Enteral Feeding in Preterm Infants: Assessing Safety and Benefits through Meta-Analysis
newsexclusive enteral feedingnecrotizing enterocolitis

Early Exclusive Enteral Feeding in Preterm Infants: Assessing Safety and Benefits through Meta-Analysis

By MedXY|Aug 14, 2026

Early exclusive enteral feeding in preterm infants is associated with faster feeding advancement and shorter hospital stay without increased risks of necrotizing enterocolitis or infection, suggesting it is a feasible and beneficial nutriti

Automated Oxygen Control vs. Manual Care: Large-Scale Trial Finds No Difference in Clinical Outcomes for Extremely Preterm Infants
Critical Careclinical trialNeonatology

Automated Oxygen Control vs. Manual Care: Large-Scale Trial Finds No Difference in Clinical Outcomes for Extremely Preterm Infants

By MedXY|Feb 14, 2026

A multicenter randomized trial of 1,082 extremely preterm infants found that automated FiO2 control did not significantly reduce death or major morbidities compared to manual titration, though it remains a safe labor-saving tool for neonata

Cerebral Oximetry-Guided Treatment Significantly Stabilizes Oxygenation in Extremely Preterm Infants: Results from a Randomized Clinical Trial
Critical CareCerebral OximetryNeonatology

Cerebral Oximetry-Guided Treatment Significantly Stabilizes Oxygenation in Extremely Preterm Infants: Results from a Randomized Clinical Trial

By MedXY|Feb 10, 2026

A randomized trial involving 100 extremely preterm infants shows that cerebral oximetry-guided treatment using a standardized guideline and NIRS device significantly reduces the burden of cerebral hypoxia and hyperoxia during the first five

Pathophysiological Divergence in Preterm Infants: Early Lung Aeration and Gas Exchange as Predictors of Moderate-to-Severe Bronchopulmonary Dysplasia
newsbronchopulmonary dysplasiaNeonatal Intensive Care

Pathophysiological Divergence in Preterm Infants: Early Lung Aeration and Gas Exchange as Predictors of Moderate-to-Severe Bronchopulmonary Dysplasia

By MedXY|Feb 8, 2026

A multicentre prospective study reveals that infants developing moderate-to-severe BPD exhibit significant lung aeration and gas exchange deficits as early as day 10, with a critical pathophysiological peak at 26 days of life, regardless of

Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials
Critical Careclinical trialoxygen therapy

Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials

By MedXY|Dec 16, 2025

Recent trials and meta-analyses challenge assumptions about optimal initial oxygen levels for preterm resuscitation.

Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial
newsdonor milkenteral feeding

Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial

By MedXY|Dec 14, 2025

In a blinded multisite RCT of 201 moderate–late preterm infants, short-term supplementation with pasteurized donor human milk versus term formula did not shorten time to full enteral feeds; donor milk was associated with slower regain of bi

Expectant Management Improves Early Survival Without Increasing BPD: Results from the PDA Randomized Clinical Trial
Cardiologyexpectant managementpatent ductus arteriosus

Expectant Management Improves Early Survival Without Increasing BPD: Results from the PDA Randomized Clinical Trial

By MedXY|Dec 12, 2025

In extremely preterm infants with a protocol-defined PDA, expectant management yielded similar rates of death or BPD at 36 weeks’ postmenstrual age but significantly higher survival compared with active pharmacologic closure.

Hydrocortisone in Preterm Infants and School-Age Functional Outcomes: Comprehensive Review of Evidence from Randomized Clinical Trials
Clinical Updateshydrocortisoneneurodevelopment

Hydrocortisone in Preterm Infants and School-Age Functional Outcomes: Comprehensive Review of Evidence from Randomized Clinical Trials

By MedXY|Dec 15, 2025

Neonatal hydrocortisone treatment in preterm infants at high risk for bronchopulmonary dysplasia does not improve school-age functional outcomes, highlighting the persistent burden of developmental impairment despite intervention.

Personalized Prediction of Platelet Transfusion Outcomes in Preterm Infants with Severe Thrombocytopenia
Hematology-Oncologyplatelet transfusionpreterm infants

Personalized Prediction of Platelet Transfusion Outcomes in Preterm Infants with Severe Thrombocytopenia

By MedXY|Oct 14, 2025

A dynamic model predicts individualized risk of major bleeding or death with or without prophylactic platelet transfusion in preterm infants, allowing tailored clinical decisions based on evolving patient status.

Evaluating Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: Insights from the BiB Randomized Clinical Trial
newsbronchopulmonary dysplasiabudesonide

Evaluating Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: Insights from the BiB Randomized Clinical Trial

By MedXY|Oct 10, 2025

The BiB trial showed that adding budesonide to surfactant did not reduce bronchopulmonary dysplasia or death in extremely preterm infants but was associated with increased hyperglycemia risk.

Enhanced Respiratory Support in Very Preterm Infants: Nasal Mask CPAP Outperforms Face Mask at Birth
newsCPAPpreterm infants

Enhanced Respiratory Support in Very Preterm Infants: Nasal Mask CPAP Outperforms Face Mask at Birth

By MedXY|Oct 8, 2025

An open-label RCT demonstrates that nasal mask CPAP at birth increases CPAP success rates and reduces the need for positive pressure ventilation compared to face mask CPAP in very preterm infants, with comparable safety profiles.

Deferred Cord Clamping with High Oxygen in Extremely Preterm Infants: Enhancing Early Oxygenation Without Added Morbidity
Clinical Updatespreterm infants

Deferred Cord Clamping with High Oxygen in Extremely Preterm Infants: Enhancing Early Oxygenation Without Added Morbidity

By MedXY|Oct 7, 2025

This review examines randomized clinical evidence that 100% oxygen during deferred cord clamping improves early oxygen saturation in extremely preterm infants without increasing morbidity, highlighting implications for neonatal resuscitatio

Darbepoetin in Preterm Infants: Enhancing Red Cell Mass without Neurodevelopmental Benefit
Clinical Updatesneuroprotectionpreterm infants

Darbepoetin in Preterm Infants: Enhancing Red Cell Mass without Neurodevelopmental Benefit

By MedXY|Oct 1, 2025

Weekly darbepoetin in extremely preterm infants increases red cell mass and reduces transfusion needs, but does not improve cognitive outcomes at 22-26 months’ corrected age.

Supplemental Donor Milk versus Infant Formula for Moderate to Late Preterm Infants: Implications from a Multisite Randomized Trial
Clinical Updatesdonor milkneonatal nutrition

Supplemental Donor Milk versus Infant Formula for Moderate to Late Preterm Infants: Implications from a Multisite Randomized Trial

By MedXY|Oct 1, 2025

A multisite RCT found no difference in time to full enteral feeds between donor human milk and formula in moderate to late preterm infants, but formula was associated with faster weight regain.

Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation
Clinical Updatesdysbiosisperinatal antibiotics

Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation

By MedXY|Dec 25, 2025

Perinatal antibiotic exposure in preterm infants disrupts gut microbiota composition, increasing pathogenic bacteria and reducing beneficial species, with implications for infection risk and the protective role of breastfeeding.

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