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A prespecified CIRCUIT analysis found that Control-IQ closed-loop insulin delivery improved intrapartum time in range and reduced early postpartum hypoglycemia versus standard care in women with type 1 diabetes, without new safety concerns.

Nephrology

cardiovascular disease

Pregnancy

Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease

By MedXY|Aug 18, 2026

Higher proteinuria in preeclampsia was linked to greater long-term risk of maternal hypertension and chronic kidney disease, with overall increased risk of cardiovascular disease as well.

OB/GYN & Women's Healthmaternal healthPregnancy

Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial

By MedXY|Aug 18, 2026

A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioi

OB/GYN & Women's HealthadherencePregnancy

Low-Dose Aspirin’s Pregnancy Benefit Appears Unchanged by Start Time or Adherence in a Large Multicentre Post Hoc Trial Analysis

By MedXY|Aug 18, 2026

In this post hoc analysis of a large randomized pregnancy trial, aspirin’s effects on preterm birth and perinatal mortality were not meaningfully modified by gestational age at initiation or measured adherence.

Diabetes & EndocrinologyPregnancyPFAS

Higher PFAS Exposure During Pregnancy Was Not Linked to Increased Gestational Diabetes in the ECHO Cohort

By MedXY|Aug 18, 2026

In a pooled U.S. pregnancy cohort, maternal PFAS concentrations were not associated with a higher prevalence of gestational diabetes, and fasting glucose findings were largely null.

CardiologyanticoagulationCardiology

Mechanical Heart Valves in Pregnancy: Navigating the High Risk of Thrombosis and the Biological Valve Advantage

By MedXY|Mar 20, 2026

The ESC EORP ROPAC III registry highlights a stark contrast in pregnancy outcomes between mechanical and biological heart valves, revealing that only 54% of women with mechanical valves achieve an uncomplicated live birth, largely due to an

Clinical UpdatesIslet Autoimmunitynutrition

Lifestyle Determinants and Metabolic Compensation in Pregnancies Complicated by Type 1 Diabetes: A Synthesis of the ENDIA Study and Recent Evidence

By MedXY|Mar 13, 2026

This review analyzes the lifestyle patterns of pregnant women with type 1 diabetes, synthesizing findings from the ENDIA study with recent evidence on nutritional adequacy, islet autoimmunity, and the molecular mechanisms of metabolic compe

Diabetes & Endocrinologychildhood obesityGestational Diabetes

Maternal Glycemic Control in Gestational Diabetes and Its Impact on Childhood Obesity

By MedXY|Mar 11, 2026

Research indicates that achieving stable and optimal blood sugar levels immediately after a gestational diabetes diagnosis can reduce a child’s risk of obesity to levels comparable to those born to mothers without the condition.

Cardiologybiomarkerscardiovascular disease

Clinical Factors and Biomarkers During Pregnancy and Risk of Cardiovascular Disease: Leveraging the ‘Natural Stress Test’

By MedXY|Mar 11, 2026

This review synthesizes findings on how pregnancy biomarkers, particularly sFlt-1 and hs-cTnI, serve as early indicators of long-term maternal cardiovascular risk, offering a unique window for sex-specific prevention.

Clinical UpdatesendocrinologyGraves' Disease

Management of Graves’ Disease During Pregnancy: Clinical Insights from the Danish PRETHYR Multicenter Study

By MedXY|Mar 9, 2026

This clinical review synthesizes findings from the PRETHYR study on antithyroid drug use in pregnant women, highlighting treatment transitions, biochemical predictors, and the impact of specialist-led management in Denmark.

Hematology-OncologyHemoglobinPregnancy

Intravenous Iron Outperforms Oral Prophylaxis in Non-Anaemic Iron-Deficient Pregnancy: A Paradigm Shift in Antenatal Care?

By MedXY|Jan 14, 2026

This multicentre RCT found that intravenous iron significantly boosts maternal hemoglobin before delivery in non-anaemic iron-deficient women compared to standard oral prophylaxis, highlighting the potential benefit of early ferritin screen

Clinical Updateslong COVIDPregnancy

Long COVID-19 in Pregnancy: Elevated Risk Amidst Mild Omicron Infection in a Boosted Vaccinated Cohort During COVID-19 Endemicity

By MedXY|Dec 24, 2025

Pregnant women show increased risk of long COVID-19 post-SARS-CoV-2 infection during Omicron predominance despite mild disease, yet incidence remains modest in a highly vaccinated cohort, highlighting vaccination’s protective role amidst em

Clinical UpdatesCOVID-19maternal outcomes

The Role of COVID-19 Vaccination in Improving Maternal and Perinatal Outcomes: A Comprehensive Review

By MedXY|Dec 24, 2025

Vaccination against SARS-CoV-2 during pregnancy significantly lowers risks of severe maternal COVID-19, hospitalization, critical care admission, and preterm birth across variant periods, underscoring its safety and efficacy for maternal an

newsCongenital MalformationsPregnancy

First-Trimester Z-Drug Exposure Does Not Increase Overall Risk of Congenital Malformations

By MedXY|Dec 23, 2025

A large-scale US cohort study of over 4.2 million pregnancies found no significant association between first-trimester Z-drug exposure—primarily zolpidem—and major congenital malformations, providing clinical reassurance for managing severe

Clinical Updatescalcium supplementationhypertensive disorders

Calcium Supplementation During Pregnancy for Preventing Hypertensive Disorders: Current Evidence and Clinical Implications

By MedXY|Dec 16, 2025

This review synthesizes recent randomized controlled trials and meta-analyses on calcium supplementation during pregnancy, evaluating its effectiveness in preventing hypertensive disorders such as pre-eclampsia and related maternal and neon

NeurologyDisease-Modifying Therapymultiple sclerosis

Pregnancy DMT Management in Multiple Sclerosis Increases Relapse Risk — Anti‑CD20 Before Conception Is Most Protective

By MedXY|Dec 11, 2025

A large French registry study shows that how disease-modifying therapies (DMTs) are managed during pregnancy meaningfully affects relapse rates in relapsing‑onset MS; prolonged natalizumab interruption and fingolimod use carry the highest r

newsPM2.5Pregnancy

Wildfire Smoke During Pregnancy Linked to Higher Preterm Birth Risk in the US West: ECHO Cohort Analysis Shows Intensity, Duration, and Timing Matter

By MedXY|Nov 23, 2025

A nationwide ECHO analysis found wildfire-specific PM2.5 exposure was associated with increased odds of preterm birth in the US West, with stronger effects for higher concentration, longer smoke waves, and mid-to-late pregnancy exposures.

newsADHDautism

Maternal Paracetamol in Pregnancy and Child Neurodevelopment: Current Evidence Does Not Establish a Clear Causal Link

By MedXY|Nov 22, 2025

An umbrella review of systematic reviews finds low to critically low confidence in studies linking prenatal paracetamol exposure to autism or ADHD; sibling-controlled analyses largely attenuate associations. Clinical guidance: use lowest ef

HIV/AIDSPregnancy

Dapivirine Ring and Oral PrEP in Pregnancy: MTN-042/DELIVER Shows Infant Safety Through 12 Months

By MedXY|Nov 12, 2025

A randomized phase 3b trial found no infant safety signals attributable to in-utero exposure to the dapivirine vaginal ring or oral tenofovir–emtricitabine PrEP over 12 months of follow-up, supporting use of both options for HIV prevention

newsbuprenorphinemethadone

Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns

By MedXY|Oct 30, 2025

This nationwide cohort study reveals higher discontinuation rates of buprenorphine than methadone during pregnancy and up to one year postpartum, highlighting significant challenges in treatment retention for opioid use disorder in pregnant

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