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Balance, Not Bedrest: Daily Movement Patterns Linked to Faster Symptom Recovery After Pediatric Concussion
NeurologyPediatricsPhysical Activity

Balance, Not Bedrest: Daily Movement Patterns Linked to Faster Symptom Recovery After Pediatric Concussion

By MedXY|Nov 8, 2025

Compositional analysis of the PedCARE cohort suggests that an early period of relative rest combined with above-average light and moderate-to-vigorous activity over the first two weeks is associated with lower postconcussion symptom burden

FDA Approves Linzess for Pediatric IBS with Constipation: A New Hope for Children
GastroenterologyconstipationFDA approval

FDA Approves Linzess for Pediatric IBS with Constipation: A New Hope for Children

By MedXY|Nov 6, 2025

The FDA has approved linaclotide (Linzess) for treating irritable bowel syndrome with constipation (IBS-C) in children 7 and older, marking the first official treatment option for pediatric IBS-C.

Darker Skin Tone Reduces Accuracy of Cerebral NIRS in Children: Implications from a Prospective Cohort
AnesthesiologyPediatrics

Darker Skin Tone Reduces Accuracy of Cerebral NIRS in Children: Implications from a Prospective Cohort

By MedXY|Nov 5, 2025

A prospective pediatric study shows forehead NIRS (INVOS 5100C) underestimates regional oxygenation in children with darker skin, producing clinically meaningful bias and raising concerns about equity in monitoring and device validation.

Unilateral Pediatric Chronic Otitis Media with Effusion Impairs Binaural Hearing and Raises Tinnitus Risk: Evidence Challenging Conservative Management
newsbinaural hearingPediatrics

Unilateral Pediatric Chronic Otitis Media with Effusion Impairs Binaural Hearing and Raises Tinnitus Risk: Evidence Challenging Conservative Management

By MedXY|Nov 4, 2025

A prospective cross-sectional study finds unilateral chronic otitis media with effusion (COME) in children is associated with poorer spatial release from masking and high tinnitus prevalence, suggesting potential central auditory consequenc

Early Cochlear Implantation Shows Variable but Clinically Relevant Benefits in Children with Single-Sided Deafness: A Western Australian 10‑Year Series
newsPediatricssingle-sided deafness

Early Cochlear Implantation Shows Variable but Clinically Relevant Benefits in Children with Single-Sided Deafness: A Western Australian 10‑Year Series

By MedXY|Nov 4, 2025

A retrospective 10‑year series from Perth Children’s Hospital reports heterogeneous long‑term outcomes after pediatric cochlear implantation for single‑sided deafness; earlier implantation (within 1 year) was associated with greater l

Common Youth Sports, Not Extra PE, Predict Lower-Extremity Apophysitis: Incidence, Duration, and Practical Implications
newsPediatricssports injury

Common Youth Sports, Not Extra PE, Predict Lower-Extremity Apophysitis: Incidence, Duration, and Practical Implications

By MedXY|Nov 4, 2025

A 5.5-year prospective cohort found lower-extremity apophysitis common in schoolchildren (1265 episodes in 1670 children), median symptom duration 3–4 weeks, and higher risk with soccer, handball, basketball and jump gymnastics but not from

Optimizing Blood Culture Use in Pediatric Infections: Insights from the ACORN2 Surveillance Network in Africa and Asia
Infectious DiseasesinfectionPediatrics

Optimizing Blood Culture Use in Pediatric Infections: Insights from the ACORN2 Surveillance Network in Africa and Asia

By MedXY|Oct 31, 2025

This study identifies clinical and demographic factors associated with positive blood cultures in hospitalized children across nine African and Asian countries, aiming to improve diagnostic stewardship amidst resource constraints.

Risk Factors and Epidemiological Trends in Severe Pediatric Invasive Group A Streptococcal Disease: Insights from the Netherlands 2015–2024
Critical Careinfectious diseasesPediatrics

Risk Factors and Epidemiological Trends in Severe Pediatric Invasive Group A Streptococcal Disease: Insights from the Netherlands 2015–2024

By MedXY|Oct 27, 2025

A comprehensive study identifies key clinical and temporal risk factors associated with severe invasive group A streptococcal disease in children, highlighting increased severity and incidence post-COVID-19 pandemic in the Netherlands.

Epstein-Barr Virus and Pediatric Sepsis: Unraveling Links to Immune Dysregulation and Mortality
Critical CareEBVEpstein-Barr virus

Epstein-Barr Virus and Pediatric Sepsis: Unraveling Links to Immune Dysregulation and Mortality

By MedXY|Oct 27, 2025

This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.

Pharmacological Treatments for Pediatric Functional Constipation: A Comprehensive Systematic Review and Meta-Analysis
Gastroenterologyfunctional constipationPediatrics

Pharmacological Treatments for Pediatric Functional Constipation: A Comprehensive Systematic Review and Meta-Analysis

By MedXY|Oct 20, 2025

This systematic review and meta-analysis evaluates the efficacy and safety of pharmacological therapies for functional constipation in children, identifying polyethylene glycol as the preferred first-line treatment based on moderate-certain

Evaluating the Incremental Benefit of Two Versus One Dose of Influenza Vaccine in Influenza-Naive Children Under Nine: A Systematic Review and Meta-Analysis
Infectious Diseasesinfluenza vaccinePediatrics

Evaluating the Incremental Benefit of Two Versus One Dose of Influenza Vaccine in Influenza-Naive Children Under Nine: A Systematic Review and Meta-Analysis

By MedXY|Oct 4, 2025

This systematic review and meta-analysis assess the additional protection from a second dose of influenza vaccine in vaccine-naive children under nine years old, highlighting significant benefits particularly for those under three years.

Diverging Pediatric Recommendations on COVID-19 Vaccination: The AAP Advocates Routine Immunization for Young Children Amid Federal Policy Shift
Allergy & ImmunologyCOVID-19 vaccinePediatrics

Diverging Pediatric Recommendations on COVID-19 Vaccination: The AAP Advocates Routine Immunization for Young Children Amid Federal Policy Shift

By MedXY|Oct 4, 2025

The American Academy of Pediatrics recommends COVID-19 vaccination for all young children aged 6-23 months, diverging from current CDC policies that advise shared decision-making for healthy children. This review analyzes epidemiologic data

Optimizing Daptomycin Use in Japanese Pediatric Patients: The Critical Roles of Dose and Renal Function
Clinical UpdatesAntibioticsPediatrics

Optimizing Daptomycin Use in Japanese Pediatric Patients: The Critical Roles of Dose and Renal Function

By MedXY|Dec 25, 2025

A multicenter study in Japan found that adequate daptomycin dosing significantly improves clinical outcomes in pediatric patients, while adverse events can occur regardless of renal function.

Avatrombopag in Pediatric Immune Thrombocytopenia: Evidence from the AVA-PED-301 Phase 3b Trial
Clinical Updatesclinical trialimmune thrombocytopenia

Avatrombopag in Pediatric Immune Thrombocytopenia: Evidence from the AVA-PED-301 Phase 3b Trial

By MedXY|Oct 1, 2025

The AVA-PED-301 phase 3b trial demonstrates avatrombopag’s efficacy and safety as an oral thrombopoietin receptor agonist for children and adolescents with persistent or chronic immune thrombocytopenia.

Multidose Ondansetron After Emergency Visits: Reducing Gastroenteritis Severity in Children
Clinical Updatesemergency medicinegastroenteritis

Multidose Ondansetron After Emergency Visits: Reducing Gastroenteritis Severity in Children

By MedXY|Sep 30, 2025

A randomized trial shows that multidose ondansetron after pediatric ED visits for gastroenteritis reduces moderate-to-severe illness, though impact on vomiting duration and healthcare utilization is limited.

Influenza-Associated Acute Necrotizing Encephalopathy in US Children
Clinical Updatesinfluenzaneurology

Influenza-Associated Acute Necrotizing Encephalopathy in US Children

By MedXY|Sep 30, 2025

A multicenter US study highlights the devastating burden of influenza-associated acute necrotizing encephalopathy in children, with high mortality and disability rates despite aggressive therapy, underscoring the urgent need for prevention

Low Hepatitis C Treatment Rates in Children: Understanding the Barriers and Opportunities
Infectious DiseasesHepatitis CPediatrics

Low Hepatitis C Treatment Rates in Children: Understanding the Barriers and Opportunities

By MedXY|Sep 30, 2025

A study published in Pediatrics reveals low rates of hepatitis C treatment among children, highlighting significant racial disparities and access challenges.

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