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A nationwide study reveals that adolescent liver transplant recipients receiving grafts from donors 10+ years older face a 12.7% reduction in 10-year graft survival. Expanding allocation radii could improve access to age-matched organs and
A longitudinal study of the ENVIRONAGE cohort reveals that blood pressure tracks consistently from birth through childhood, with higher neonatal readings significantly increasing the risk of hypertension by age 11, emphasizing the need for
This comprehensive systematic review and meta-analysis of 190 studies involving 2.8 million participants establishes a 4.7% incidence rate for childhood food allergy and identifies early atopic conditions, microbiome disruptions, and delaye
A multicenter cohort study of 8,874 pediatric patients reveals that most prophylactic platelet transfusions occur above recommended thresholds. Factors such as pathogen reduction, additive solutions, and donor age significantly lower posttr
A comprehensive study highlights that over half of publicly insured children develop neurodevelopmental disorders within five years of infant cardiac surgery. While service utilization is high, a critical gap persists between initial screen
New clinical trials reveal that adding acetaminophen or hydromorphone to ibuprofen provides no additional pain relief for children with acute musculoskeletal injuries, while the addition of opioids significantly increases the risk of advers
A pilot randomized clinical trial reveals that text-based digital stories centered on community voices significantly improved influenza vaccination rates among children in Black communities, even though only 7% of caregivers viewed the narr
The VITALITY trial reveals that while high-dose vitamin D and calcium supplementation did not benefit all adolescents with HIV, it significantly improved bone density in those with baseline vitamin D insufficiency, providing a safe strategy
A whole-population study from 2012–2023 reveals that while confirmed child maltreatment cases declined overall, disparities for Black children and female victims of sexual abuse remained stagnant or worsened, highlighting critical gaps in p
A multicenter study reveals that economic instability—specifically food insecurity—and poor social/community contexts significantly increase the odds of long COVID in US children and adolescents, highlighting the critical role of social det
A comprehensive BMJ umbrella review synthesizes evidence for ADHD interventions across the lifespan, confirming the efficacy of stimulants and non-stimulants in the short term while revealing a critical lack of high-certainty long-term data
Recent real-world data from the US and France indicate that while both maternal RSV vaccination and nirsevimab are effective, nirsevimab may offer superior protection against hospitalization and intensive care admission for infants in their
This interim analysis of the phase 4 EPI-MAL-003 study demonstrates that the RTS,S/AS01E malaria vaccine significantly reduces severe malaria, malaria-related hospitalizations, and all-cause hospitalizations in real-world clinical settings
This article evaluates the optimal timing and indications for caffeine initiation in preterm neonates, analyzing its impact on chronic lung disease, mortality, and neurodevelopmental outcomes based on the latest 2025 Cochrane evidence.
Updated Cochrane analysis (212 RCTs, 16,302 participants) finds methylphenidate may reduce teacher-rated ADHD symptoms and improve general behaviour but increases non‑serious adverse events; overall evidence certainty is very low.
The FEED1 trial randomized 2088 infants born at 30+0 to 32+6 weeks to full enteral feeds from day 1 versus gradual feeding with IV support. Full feeds did not shorten hospital stay and showed no increase in necrotising enterocolitis or clin
A nationwide French multicentre cohort (ORIGAMI) documents a substantial 2023–24 paediatric hospitalisation surge from Mycoplasma pneumoniae, identifies older age, asthma, comorbidity and erythema multiforme as ICU risk factors, and highlig
A phase 3 immunobridging study found that a single dose of recombinant quadrivalent influenza vaccine (RIV4) induced non‑inferior HAI responses in 9–17‑year‑olds vs 18–49‑year‑olds, with a comparable safety profile and fewer solicited react
A multicenter randomized noninferiority trial found that GP observation after pediatric ventilation tube insertion produced audiometric outcomes at 2 years that were noninferior to routine ENT follow-up, with no increase in complications.
A nested PK and safety sub‑study of D3/PENTA 21 shows once‑daily DTG/3TC dispersible and film‑coated fixed‑dose tablets deliver adequate drug exposures across WHO weight bands in children 2–<15 years, with no drug‑related discontinuation
