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LINC01521 is significantly upregulated in papillary thyroid carcinoma, promoting tumor progression by targeting miR-4319 and inhibiting cuproptosis, thereby serving as an independent prognostic marker for adverse clinical outcomes.
This analysis reveals that TERT promoter mutations, increasingly prevalent with age, better predict poor outcomes in papillary thyroid carcinoma than age alone, offering enhanced risk stratification for clinical management.
A new sonographic pattern characterized by discontinuous peripheral punctate echogenic foci (DPEF) in thyroid nodules is strongly associated with papillary thyroid carcinoma (PTC), suggesting its potential as an important diagnostic marker
In papillary thyroid carcinoma treated with thyroidectomy and RAI, TgAb levels above the assay’s limit of quantification identified patients with higher long-term recurrence risk despite undetectable serum thyroglobulin.
A large South Korean cohort found ATA-guideline de-escalation reduced total thyroidectomy, RAI use, and permanent hypocalcemia in papillary thyroid carcinoma, without significant loss of 5-year disease-free survival.
A real-world study validates the 2025 ATA thyroid cancer risk guidelines, showing significant patient reclassification and identifying a new ‘low-intermediate-risk’ group needing tailored management approaches.
A retrospective study of 670 papillary thyroid carcinoma patients validates the 2025 ATA risk stratification system, demonstrating a shift toward higher-risk classifications. The new ‘low-intermediate-risk’ class emerges as a di
A comprehensive meta-analysis suggests that for intermediate-risk papillary thyroid carcinoma with unilateral lateral lymph node metastasis, lobectomy provides oncological outcomes comparable to total thyroidectomy, challenging the necessit
A multicenter study in China demonstrates that radioactive iodine therapy may not significantly improve structural or biochemical response rates in T1-T2 stage papillary thyroid carcinoma with lymph node metastasis, highlighting the lymph n
A large-scale SEER database study reveals that total thyroidectomy significantly improves disease-specific survival for patients with cN1b papillary thyroid cancer. However, this survival advantage is attenuated in younger populations, pote
A multicenter study challenges the mandatory use of total thyroidectomy and radioactive iodine in all patients with lateral neck metastasis (cN1b) papillary thyroid carcinoma, suggesting that lobectomy may offer comparable oncologic outcome
A landmark propensity-matched study from Memorial Sloan Kettering Cancer Center demonstrates that thyroid lobectomy with neck dissection provides similar survival and recurrence outcomes to total thyroidectomy plus radioactive iodine for sp
