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Low-frequency repetitive transcranial magnetic stimulation targeting the medial prefrontal cortex reduces visceral pain and improves bowel symptoms in IBS-D by normalizing central neural hyperexcitability.
In a sham-controlled trial, translumbosacral neuromodulation with 2400 or 3600 magnetic pulses reduced fecal incontinence episodes, improved severity scores and quality of life, and was well tolerated, with the higher dose showing the stron
This randomized pilot study demonstrates that high-frequency TENS significantly improves specific neuropathic ocular pain symptoms over three months, offering a non-invasive, non-pharmacological alternative for patients with refractory ocul
A double-blind RCT involving 240 patients reveals that combining rTMS and tDCS significantly improves remission rates and symptom reduction in Major Depressive Disorder with comorbid anxiety compared to single-modality or sham treatments, p
The ESTIVAL trial investigated transcutaneous auricular vagus nerve stimulation (taVNS) for erosive hand osteoarthritis. While the primary pain reduction endpoint was not met, the therapy proved safe and showed potential efficacy in patient
A randomized clinical trial demonstrates that home-based gamma transcranial alternating current stimulation (tACS) over the precuneus safely improves cognitive outcomes and activities of daily living in patients with prodromal and mild Alzh
AI-driven transcutaneous peripheral nerve stimulation (TPNS) shows significant improvements in upper limb function for essential tremor (ET), supporting a promising noninvasive treatment approach with manageable safety profile over 90 days.
This international trial demonstrates that personalized adaptive deep brain stimulation (aDBS) is a safe, effective, and well-tolerated long-term therapy for Parkinson’s disease patients previously stable on continuous DBS.
This review synthesizes evidence on bilateral continuous theta burst stimulation (cTBS) of the temporo-parietal cortex for persistent auditory verbal hallucinations (AVH) in schizophrenia, focusing on a landmark German phase 3 trial demonst
A double-blind, randomized trial demonstrates that electrical vestibular stimulation (VeNS) significantly reduces insomnia severity and improves quality of life in adults, highlighting a novel non-pharmacological treatment option.
A randomized clinical trial demonstrates that personalized high-definition transcranial direct current stimulation (HD-tDCS) significantly improves mood in patients with moderate to severe depression, showing faster and comparable effect si
This review synthesizes recent clinical evidence on transcranial magnetic stimulation across neurological and psychiatric disorders, highlighting efficacy, optimization challenges, and future research directions.