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This study evaluates the impact of Long COVID on pregnancy outcomes, finding no significant risk for preterm birth but a potential association with hypertensive disorders, underscoring the need for further research.
This article explores how intestinal flagellin drives systemic inflammation via the TLR5-IL-15-ARA pathway in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD, highlighting potential therapeutic targets and biomarkers.
Flagellated gut bacteria activate TLR5 on neutrophils, triggering IL-15 release and macrophage arachidonic acid production, driving systemic inflammation in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD.
A randomized trial of 399 adults with long COVID fatigue found that fluvoxamine significantly reduced fatigue severity at 60 and 90 days compared to placebo, while metformin showed no benefit. The study represents a potential breakthrough i
A randomized clinical trial indicates that neither metformin nor ursodeoxycholic acid (UDCA) significantly improves recovery from postacute sequelae of SARS-CoV-2 (PASC) compared to placebo, highlighting the ongoing challenge of finding eff
A multicenter study reveals that economic instability—specifically food insecurity—and poor social/community contexts significantly increase the odds of long COVID in US children and adolescents, highlighting the critical role of social det
A multi-center randomized clinical trial published in JAMA Internal Medicine demonstrates that colchicine, despite its potent anti-inflammatory properties, fails to improve 6-minute walk test distances or inflammatory markers in patients su
Pregnant women show increased risk of long COVID-19 post-SARS-CoV-2 infection during Omicron predominance despite mild disease, yet incidence remains modest in a highly vaccinated cohort, highlighting vaccination’s protective role amidst em
A concise guide to the newly published Core Outcome Set for Post COVID-19 Condition (COS‑PCC): the nine prioritized outcomes, recommended measurement instruments, timing considerations, and implications for research and care.
A multicenter phase 2 randomized trial found no differential benefit of adaptive computerized cognitive training, structured cognitive rehabilitation, or transcranial direct current stimulation (tDCS) versus active comparators for self‑repo
A large prospective study demonstrates that olfactory dysfunction is prevalent and often clinically unrecognized long after SARS-CoV-2 infection, highlighting the value of formal smell testing in patient care and cognitive risk assessment.
Wearable device data reveal distinct physiological and behavioral patterns reflecting symptom heterogeneity in long COVID, without significant differences between nirmatrelvir-ritonavir and placebo arms.
Long COVID patients exhibit distinct mitochondrial bioenergetic impairments, with altered ATP synthase function correlating with clinical symptoms and quality of life, implicating mitochondrial dysfunction in its pathogenesis.
Observational data from the RECOVER Initiative suggest that SARS-CoV-2 reinfection raises the risk of long COVID by 35% relative to single infections, with more recent vaccination potentially mitigating this risk.
Long COVID is keeping millions of workers out of the workforce, with significant barriers to compensation and treatment. Standardized diagnostics, validated therapies, and regulatory reforms are urgently needed to support affected individua
Obesity influences the long-term effects of SARS-CoV-2, revealing diverse outcomes in primates and suggesting broader implications for humans.