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This international multicenter study reveals low immediate mortality after pediatric first variceal hemorrhage, with outcomes strongly influenced by underlying diagnosis, disease severity, and center-specific practices.
Alpha-1 antitrypsin deficiency (AATD) Z-allele carriers, including heterozygotes and homozygotes, exhibit progressively increased risk of adverse liver outcomes, emphasizing the need for early diagnosis and vigilant monitoring.
Researchers developed and validated the FMO score, a noninvasive, cost-effective tool to identify at-risk metabolic dysfunction-associated steatohepatitis (MASH) in obese patients, showing strong predictive performance across multiple inter
The DREAM method enables complete enteral nutrition in short bowel syndrome, enhancing intestinal adaptation and protecting liver function by restoring gut-liver signaling pathways, as demonstrated in a neonatal pig model.
New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.
A landmark multicohort study of 1,168 individuals reveals that gut microbiome diversity systematically declines across liver disease stages, with specific bacterial markers like Veillonella and functional metabolic shifts predicting disease
This large-scale prospective cohort study identifies specific spleen length and volume thresholds that significantly increase the 5-year risk of hematologic malignancies and liver disease, providing a data-driven framework for clinical work
The phase II ELMWOOD trial demonstrates that elafibranor, a dual PPAR-α/δ agonist, is well tolerated and significantly improves biochemical markers in patients with primary sclerosing cholangitis over 12 weeks, warranting further investigat
This meta-analysis reveals that short-term mortality in severe alcohol-associated hepatitis remains high, with no significant improvement over the past four decades despite advances in care, underscoring the urgent need for better therapies
Fish oil offers health benefits but is not suitable for everyone. Learn about the seven groups who should avoid fish oil to prevent health risks and ensure safe supplement use.
A new study highlights the growing prevalence of extreme pediatric obesity in the U.S. and its association with serious metabolic and cardiovascular health risks, emphasizing the need for targeted interventions.
