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Decoding Ketamine’s Neurophysiology Under General Anesthesia: Insights for Targeted Therapeutics
AnesthesiologyEEG OscillationsKetamine

Decoding Ketamine’s Neurophysiology Under General Anesthesia: Insights for Targeted Therapeutics

By MedXY|Jun 26, 2026

This study reveals that general anesthesia selectively modulates ketamine-induced EEG changes, preserving beta-gamma oscillations while attenuating theta augmentation, highlighting discrete neurophysiologic components underlying ketamine&#8

Ketamine vs. Etomidate: Does Your Choice of Induction Agent Influence Mortality in the Critically Ill?
Anesthesiologyemergency medicineEtomidate

Ketamine vs. Etomidate: Does Your Choice of Induction Agent Influence Mortality in the Critically Ill?

By MedXY|Dec 18, 2025

This article explores recent evidence comparing ketamine and etomidate for rapid sequence intubation. While new cohort data suggests a mortality benefit for ketamine, meta-analyses of randomized trials show clinical equipoise, highlighting

Ketamine or Etomidate for Tracheal Intubation? Unpacking the RSI Trial Findings on Mortality and Hemodynamics
Anesthesiologycritical careEtomidate

Ketamine or Etomidate for Tracheal Intubation? Unpacking the RSI Trial Findings on Mortality and Hemodynamics

By MedXY|Dec 18, 2025

The large-scale RSI randomized trial found no significant difference in 28-day mortality between ketamine and etomidate for intubating critically ill adults, though ketamine was associated with a higher risk of cardiovascular collapse.

Evaluating Serial Ketamine Infusions as Adjuncts in Inpatient Depression Care: Insights from the KARMA-Dep 2 Trial
newsKetaminemajor depression

Evaluating Serial Ketamine Infusions as Adjuncts in Inpatient Depression Care: Insights from the KARMA-Dep 2 Trial

By MedXY|Oct 24, 2025

The KARMA-Dep 2 trial reveals that serial ketamine infusions do not significantly outperform midazolam in reducing depressive symptoms among inpatients receiving usual psychiatric care, challenging assumptions about ketamine’s long-term ant

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