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A randomized controlled crossover trial found that individualized exclusion diets based on confocal laser endomicroscopy (CLE) findings do not significantly improve symptoms in irritable bowel syndrome (IBS) patients compared to sham diets.
This study elucidates how faecal proteases and immune proteins distinctly activate enteric neurons in IBS subtypes, revealing subtype-specific pathological mechanisms and potential diagnostic biomarkers, highlighting novel therapeutic targe
Defecation urgency in IBS is a complex symptom intertwining sensory thresholds and emotional processing, reflected in distinct brain structural changes identified through MRI. Differentiating experimentally induced versus real-life urgency
A large 26-country survey found that post-infection disorders of gut-brain interaction account for 10.5% of DGBI cases and are linked to younger age, male sex, urban living, anxiety, and greater somatic symptom burden.
A randomized clinical trial published in the Annals of Internal Medicine reveals that the Mediterranean diet is superior to traditional dietary advice for managing IBS symptoms, offering a nutrient-dense, sustainable first-line intervention
Clinical trials reveal that Rifaximin provides faster symptom relief and significantly better adherence than the low FODMAP diet in IBS patients, while also potentially restoring lactase activity in those with small intestinal bacterial ove
A multicenter RCT found that ethosuximide, a T-type calcium channel blocker, did not improve abdominal pain in IBS patients compared to placebo and was associated with significant tolerability issues, highlighting the need for more selectiv
Nonceliac gluten/wheat sensitivity affects about 1 in 10 people worldwide, with strong links to female sex, psychological distress, and irritable bowel syndrome. This article explores its prevalence, symptoms, challenges in diagnosis, and i
One in five UK patients with Rome IV IBS regularly use opioids, associated with worse quality of life, more psychological distress, and increased healthcare costs, highlighting a critical need for opioid stewardship in IBS management.
The CARIBS trial shows that both low FODMAP plus traditional dietary advice and a low-carbohydrate diet outperform optimized pharmacologic treatment in reducing IBS symptom severity after 4 weeks, highlighting the importance of dietary inte
A rigorous trial reveals that perceived symptom worsening from gluten or wheat in IBS patients may largely be driven by expectation rather than the substances themselves, underscoring the importance of distinguishing true sensitivities from
