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This nationwide Swedish study tracks shifting predictors of critical illness during different COVID-19 pandemic periods and compares them to seasonal influenza, highlighting vaccination status and age as key risk factors for severe outcomes
This longitudinal study characterizes symptom variability and outcomes of respiratory infections among young children, revealing age-specific severity patterns and notable differences between influenza A and B.
A comprehensive single-cell atlas of lung immune cells reveals distinct immune responses in mild versus severe influenza, highlighting neutrophil dysfunction and lymphocyte impairment as key drivers of pathology.
Intensive oseltamivir chemoprophylaxis for ≥70% of nursing home residents within 2 days of influenza outbreak reduces hospitalization risk, underscoring prompt antiviral intervention as a critical outbreak control strategy.
Prompt oseltamivir prophylaxis covering at least 70% of eligible nursing home residents within 2 days of outbreak detection was associated with fewer hospitalizations, but not lower mortality.
In a real-world target trial emulation, starting oseltamivir prophylaxis within 2 days for at least 70% of eligible nursing home residents was linked to fewer hospitalizations, but not lower short-term mortality.
A secondary analysis of the DANFLU-2 trial confirms that high-dose influenza vaccine significantly reduces cardiorespiratory hospitalizations in older adults with diabetes, with potentially enhanced benefits for those with longer disease du
A retrospective study of 148 state-level seasons reveals that RSV typically peaks three weeks before influenza, while COVID-19 lacks consistent seasonality, providing a critical framework for optimizing hospital resource allocation and vacc
Electronic behavioral nudges significantly improve influenza vaccination rates among patients with chronic and cardiovascular diseases, offering scalable public health strategies.
The FLUNITY-HD pooled analysis of over 466,000 older adults demonstrates that high-dose inactivated influenza vaccine (HD-IIV) significantly reduces hospitalizations for influenza, pneumonia, and cardiovascular causes, including a 21.3% red
A new influenza strain, Subclade K (AH3N2 J.2.4.1), is dominating Europe’s flu season with a 90% prevalence rate. Experts emphasize that while the strain is highly transmissible, vaccination remains the most effective tool for prevent
The DANFLU-2 trial found that while high-dose influenza vaccines significantly reduced influenza-specific hospitalizations in older adults, they did not reach statistical significance for the combined primary endpoint of influenza or pneumo
The Infectious Diseases Society of America now recommends annual high-dose or adjuvanted influenza vaccine and a single RSV dose for most immunocompromised persons; timing around immunosuppression and household immunization are emphasized.
Emerging H3N2 subclade K has driven increased influenza activity abroad and may seed the 2025–26 northern hemisphere season. Surveillance gaps complicate risk assessment; vaccination and early antiviral use remain central clinical strategie
This article reviews two types of flu vaccines for children—live attenuated and inactivated—over 20 years, demonstrating both provide meaningful protection and highlighting improvements that have enhanced their effectiveness.
This study evaluates clinical testing trends for COVID-19, influenza, and RSV among hospitalized children from 2016 to 2024, revealing shifts in testing frequency and identifying factors influencing test utilization.
Antiviral prescriptions for children at high risk of severe influenza in US pediatric emergency departments decreased by over 50% during the COVID-19 pandemic compared with prepandemic rates, despite unchanged treatment guidelines.
A large US study finds adjuvanted and high-dose quadrivalent influenza vaccines provide comparable protection against lab-confirmed flu in seniors, supporting current immunization guidelines.
A multicenter US study highlights the devastating burden of influenza-associated acute necrotizing encephalopathy in children, with high mortality and disability rates despite aggressive therapy, underscoring the urgent need for prevention
