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Immunomodulatory Effects of Clarithromycin in Community-Acquired Pneumonia: Insights from the ACCESS Trial’s Inflammatory Proteome Analysis

This study reveals that clarithromycin modulates inflammatory cytokines in community-acquired pneumonia, identifying distinct immune endotypes that may guide personalized immunomodulatory therapy.

Oct 24, 2026
Diabetes & Endocrinology

Systemic Interleukin-6 Inhibition as a Novel Approach to Reduce Diabetic Retinopathy Risk and Progression

Systemic IL-6 inhibitors are linked to significantly reduced risks of diabetic retinopathy development, progression, and vision-threatening complications, suggesting therapeutic potential for diabetic eye disease.

Aug 6, 2026
Allergy & Immunology

Beyond Th2: Single-Dose Aletekitug Targets IL-18 to Deliver Sustained Clinical and Molecular Remission in Atopic Dermatitis

A phase 1/2 study reveals that a single dose of aletekitug, an anti-IL-18 antibody, provides durable clinical improvement and broad molecular modulation in moderate-to-severe atopic dermatitis, targeting pathways beyond traditional Type 2 i

Mar 5, 2026
Allergy & Immunology

Targeted HEV Modulation: A Novel Antibody-Drug Conjugate Strategy to Overcome Cardiac Allograft Rejection

Researchers have developed a first-in-class antibody-drug conjugate targeting High Endothelial Venules via the CHST4 enzyme. This therapy promotes regulatory T cell induction and long-term heart transplant survival in murine models using si

Feb 28, 2026

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