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This article details how BCKDK, a hypoxia-induced kinase, disrupts branched-chain amino acid metabolism to worsen neuronal injury in cerebral ischemia, highlighting its potential as a novel therapeutic target.
BACH1 stabilization under hypoxia promotes pulmonary hypertension by enhancing TGFBR2/SMAD pathway activity in pulmonary artery smooth muscle cells, suggesting BACH1 as a promising therapeutic target for PH.
This study reveals that hypoxia in centrally located EGFR-mutant lung adenocarcinomas drives an alveolar lineage imbalance via the ZAKα-MAPK-c-Fos pathway, promoting early tumorigenesis. Therapeutic oxygenation can restore lineage balance a
A groundbreaking multicentre study develops a clinical-radiologic model integrating hypoxia and immune phenotype signatures to accurately predict prognosis in hepatocellular carcinoma patients treated with transarterial chemoembolisation, p
This review synthesizes evidence from randomized controlled trials on environmental stress-based therapies—cold, heat, contrast, and hypoxia—for enhancing muscle recovery after exercise-induced muscle damage, emphasizing the importance of a
